Burry H C, Dieppe P A, Bresnihan F B, Brown C
Br Med J. 1976 Mar 13;1(6010):613-5. doi: 10.1136/bmj.1.6010.613.
The effect of salicylate treatment on the kidney, particularly medullary function, was investigated. In a retrospective analysis patients with rheumatoid arthritis (RA) treated with high doses of salicylates were shown to have inferior urinary concentrating power and increased excretion of N-acetyl-beta-D-glucosaminidase (NAG) when compared with patients who had not received salicylate treatment. A prospective study of renal funcition in healthy people and patients with RA starting salicylate in therapeutic doses showed that while epithelial cell excretion was only transiently raised in both groups the excretion of NAG was increased in all cases at three days and this increase was sustained at 10 days, all values being much higher in the patients than in the healthy subjects. Thus salicylate treatment does cause renal tubular damage but this damage results in only minimal impairment of function and does not constitute a reason for withholding salicylate treatment.
研究了水杨酸盐治疗对肾脏，特别是髓质功能的影响。在一项回顾性分析中，与未接受水杨酸盐治疗的患者相比，接受高剂量水杨酸盐治疗的类风湿性关节炎（RA）患者的尿液浓缩能力较差，N-乙酰-β-D-氨基葡萄糖苷酶（NAG）排泄增加。一项针对健康人和开始接受治疗剂量水杨酸盐治疗的RA患者的肾功能前瞻性研究表明，虽然两组上皮细胞排泄仅短暂升高，但三天时所有病例中NAG排泄均增加，且在10天时这种增加持续存在，患者的所有值均远高于健康受试者。因此，水杨酸盐治疗确实会导致肾小管损伤，但这种损伤仅导致功能轻微受损，并不构成停用水杨酸盐治疗的理由。
