Perez R V, Munda R, Alexander J W
Department of Surgery, University of Cincinnati College of Medicine 45267-0558.
Transplantation. 1988 Mar;45(3):614-7. doi: 10.1097/00007890-198803000-00022.
Dietary supplementation with fatty acids was carried out to examine whether the type and timing of dietary manipulation would have an effect on transfusion-induced immunosuppression in a rat cardiac transplant model. Linoleic acid (LA), oleic acid (OA), and fish oil (FO) were used because of their different effects on arachidonic acid (AA) metabolism. Pretransplant inhibition of AA metabolism (OA) shortened graft survival when compared with water-fed controls. Posttransplant LA (AA precursor) significantly prolonged graft survival. Pre- and posttransplant supplementation of LA and OA resulted in even more prolongation and shortening of graft survival, respectively. These findings suggest that transfusion-induced immunosuppression is partially mediated by AA metabolites, which are necessary for the pretransplant induction and posttransplant maintenance of the suppressed state. Dietary immunoregulation of transfusion induced immunosuppression is possible. The timing of dietary intervention and type of lipid supplementation is important in regulation of the immune response.
在大鼠心脏移植模型中，进行了脂肪酸膳食补充实验，以研究饮食调控的类型和时间是否会对输血诱导的免疫抑制产生影响。使用亚油酸（LA）、油酸（OA）和鱼油（FO）是因为它们对花生四烯酸（AA）代谢有不同影响。与饮水对照相比，移植前抑制AA代谢（OA）会缩短移植物存活时间。移植后给予LA（AA前体）可显著延长移植物存活时间。移植前和移植后补充LA和OA分别导致移植物存活时间进一步延长和缩短。这些发现表明，输血诱导的免疫抑制部分由AA代谢产物介导，这些代谢产物对于移植前免疫抑制状态的诱导和移植后维持是必需的。对输血诱导的免疫抑制进行饮食免疫调节是可能的。饮食干预的时间和脂质补充的类型在免疫反应调节中很重要。
