Department of Breast Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China (mainland).
Department of Cardiology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, China (mainland).
Med Sci Monit. 2020 Jun 25;26:e923630. doi: 10.12659/MSM.923630.
BACKGROUND The effects of marital status on infiltrating ductal carcinoma of breast cancer (IDC) have not been studied in detail. This study investigated the impact of marital status on IDC patients. MATERIAL AND METHODS SEER databases were searched from 2010 to 2015 for subjects who were married, divorced, single, and widowed. The influence of marital status on breast cancer-specific survival (BCSS) and overall survival (OS) of IDC patients was investigated through multivariate Cox regression analysis and Kaplan-Meier analysis. To prevent bias, propensity score matching (PSM) analysis was performed. RESULTS The 5-year OS was 89.6%in married patients, 84.9% in divorced patients, 83.5% in single patients, and 71.3% in widowed patients (p<0.001). The 5-year BCSS were 92.9%, 90.2%, 87.6%, and 86.4%, respectively (p<0.001). Multivariate Cox regression analysis revealed that marriage was a protective factor for patients with IDC in terms of OS (divorced: HR, 1.27; 95% CI, 1.21-1.32; p<0.001; single: HR, 1.36; 95% CI, 1.31-1.42; p<0.001; widowed: HR, 1.42; 95% CI, 1.36-1.48; p<0.001) and BCSS (divorced: HR, 1.15; 95% CI, 1.09-1.21; p<0.001; single: HR, 1.27; 95% CI, 1.21-1.33; p<0.001; widowed: HR, 1.32; 95% CI, 1.25-1.40; p<0.001). Following subgroup and PSM analysis, married patients were shown to have better OS and BCSS as opposed to divorced, single, or widowed patients. CONCLUSIONS We identify marital status as a predictor of survival in those with IDC. Widowed patients showed the highest mortality risk.
婚姻状况对浸润性导管乳腺癌（IDC）的影响尚未得到详细研究。本研究探讨了婚姻状况对 IDC 患者的影响。
从 2010 年至 2015 年，SEER 数据库中搜索了已婚、离婚、单身和丧偶的患者。通过多变量 Cox 回归分析和 Kaplan-Meier 分析，研究了婚姻状况对 IDC 患者的乳腺癌特异性生存（BCSS）和总体生存（OS）的影响。为了防止偏差，进行了倾向评分匹配（PSM）分析。
已婚患者的 5 年 OS 为 89.6%，离婚患者为 84.9%，单身患者为 83.5%，丧偶患者为 71.3%（p<0.001）。5 年 BCSS 分别为 92.9%、90.2%、87.6%和 86.4%（p<0.001）。多变量 Cox 回归分析表明，婚姻是 IDC 患者 OS 的保护因素（离婚：HR，1.27；95%CI，1.21-1.32；p<0.001；单身：HR，1.36；95%CI，1.31-1.42；p<0.001；丧偶：HR，1.42；95%CI，1.36-1.48；p<0.001）和 BCSS（离婚：HR，1.15；95%CI，1.09-1.21；p<0.001；单身：HR，1.27；95%CI，1.21-1.33；p<0.001；丧偶：HR，1.32；95%CI，1.25-1.40；p<0.001）。在亚组和 PSM 分析后，与离婚、单身或丧偶患者相比，已婚患者的 OS 和 BCSS 更好。
我们将婚姻状况确定为 IDC 患者生存的预测因素。丧偶患者的死亡率风险最高。
