Vega-Rúa Anubis, Marconcini Michele, Madec Yoann, Manni Mosè, Carraretto Davide, Gomulski Ludvik Marcus, Gasperi Giuliano, Failloux Anna-Bella, Malacrida Anna Rodolfa
Laboratory of Vector Control Research, Institut Pasteur of Guadeloupe, 97139, Guadeloupe, France.
Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100, Pavia, Italy.
Commun Biol. 2020 Jun 24;3(1):326. doi: 10.1038/s42003-020-1046-6.
The mosquito Aedes albopictus is one of the most dangerous invasive species. Its worldwide spread has created health concerns as it is a major vector of arboviruses of public health significance such as chikungunya (CHIKV). Dynamics of different genetic backgrounds and admixture events may have impacted competence for CHIKV in adventive populations. Using microsatellites, we infer the genetic structure of populations across the expansion areas that we then associate with their competence for different CHIKV genotypes. Here we show that the demographic history of Ae. albopictus populations is a consequence of rapid complex patterns of historical lineage diversification and divergence that influenced their competence for CHIKV. The history of adventive populations is associated with CHIKV genotypes in a genotype-by-genotype interaction that impacts their vector competence. Thus, knowledge of the demographic history and vector competence of invasive mosquitoes is pivotal for assessing the risk of arbovirus outbreaks in newly colonized areas.
白纹伊蚊是最危险的入侵物种之一。它在全球范围内的传播引发了健康担忧，因为它是诸如基孔肯雅病毒（CHIKV）等具有公共卫生意义的虫媒病毒的主要传播媒介。不同遗传背景和混合事件的动态变化可能影响了外来种群对基孔肯雅病毒的易感性。利用微卫星，我们推断了扩张区域内种群的遗传结构，然后将其与它们对不同基孔肯雅病毒基因型的易感性联系起来。在这里，我们表明白纹伊蚊种群的种群历史是历史谱系快速复杂的多样化和分化模式的结果，这些模式影响了它们对基孔肯雅病毒的易感性。外来种群的历史与基孔肯雅病毒基因型在逐个基因型的相互作用中相关联，这种相互作用影响它们的媒介易感性。因此，了解入侵蚊子的种群历史和媒介易感性对于评估新殖民地区虫媒病毒爆发的风险至关重要。
