Pauli G, Bessot J C, Braun P A, Dietemann-Molard A, Kopferschmitt-Kubler M C, Thierry R
Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France.
Ann Allergy. 1988 Mar;60(3):243-6.
In 20 patients, the ingestion of celery was responsible for mucocutaneous symptoms (generalized urticaria and angioedema) (18/20) and respiratory disorders (7/20). Four cases of systemic anaphylaxis were observed. The main associated allergic disorder was pollinosis (16/20). Food allergy to other vegetable products, mainly other Umbelliferae and apples, coexisted with celery allergy in 12 cases. It was found that celery allergy is mediated by IgE antibodies: it is easily diagnosed by skin tests (fresh extracts of celery may be used) and by adequate RAST (17 positive results). Cosensitization with mugwort pollen (14 cases) and birch pollen (9 cases) was found. Celery allergens responsible for clinical sensitization originate chiefly in the tuber and are at least partly thermally labile. The frequent association with pollen sensitization suggests the existence of common antigenic epitopes in celery extracts and mugwort and birch pollens. The immunologic investigations carried out so far (RAST inhibition and immunoprint) seem to support this hypothesis.
在20例患者中，摄入芹菜导致了皮肤黏膜症状（全身性荨麻疹和血管性水肿）（18/20）以及呼吸系统疾病（7/20）。观察到4例全身性过敏反应。主要相关的过敏性疾病是花粉症（16/20）。对其他蔬菜产品的食物过敏，主要是其他伞形科植物和苹果，在12例中与芹菜过敏共存。发现芹菜过敏由IgE抗体介导：通过皮肤试验（可使用芹菜新鲜提取物）和适当的放射性变应原吸附试验（RAST）很容易诊断（17个阳性结果）。发现与艾蒿花粉（14例）和桦树花粉（9例）存在共同致敏。导致临床致敏的芹菜过敏原主要源于块茎，且至少部分对热不稳定。与花粉致敏的频繁关联表明芹菜提取物与艾蒿花粉和桦树花粉中存在共同的抗原表位。迄今为止进行的免疫学研究（RAST抑制和免疫印迹）似乎支持这一假说。
