Yanch J C, Irvine A T, Webb S, Flower M A
Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey.
Br J Radiol. 1988 Mar;61(723):221-5. doi: 10.1259/0007-1285-61-723-221.
A method of improving the quality of images in single photon emission computed tomography (SPECT) is demonstrated using transaxial images of the liver and brain. Deconvolution of the nuclear medicine data by a point source response function (PSRF) acquired previously in a scattering medium attempts to compensate for scattered radiation within the patient. The average geometric response of the collimator of the gamma camera is also compensated for with this technique. Three patients with known metastatic lesions in the liver and three with primary lesions in the brain were imaged. Clinical assessment of reconstructed slices both before and after deconvolution demonstrates that compensating for the effects of scatter and of collimator blurring leads to enhanced detail of pathological lesions. In all cases, cold lesions seen prior to deconvolution were enhanced in detail and, in addition, new lesions were seen with this technique.
利用肝脏和大脑的断层图像，展示了一种提高单光子发射计算机断层扫描（SPECT）图像质量的方法。通过先前在散射介质中获取的点源响应函数（PSRF）对核医学数据进行去卷积，试图补偿患者体内的散射辐射。该技术还对伽马相机准直器的平均几何响应进行了补偿。对三名已知肝脏有转移病灶的患者和三名脑部有原发性病灶的患者进行了成像。对去卷积前后重建切片的临床评估表明，补偿散射和准直器模糊的影响可增强病理病灶的细节。在所有病例中，去卷积前看到的冷病灶细节得到增强，此外，该技术还发现了新的病灶。
