Cordina Steve M, Afarian Shant, Gerthoffer William T, Martino Anthony, Wilson Russell, Naritoku Dean K
Department of Neurology, University of South Alabama College of Medicine, Mobile, AL, United States.
Department of Neurosurgery, University of South Alabama College of Medicine, Mobile, AL, United States.
Front Neurol. 2020 Jun 3;11:439. doi: 10.3389/fneur.2020.00439. eCollection 2020.
The growth and eventual rupture of intracranial aneurysms may be due to an underlying inflammatory process as evidenced by pathological examination of aneurysm walls. We hypothesize that unruptured aneurysms have an increased inflammatory milieu within their lumen in comparison to the rest of the cerebral arterial vascular system. Blood was sampled from unruptured aneurysms in patients presenting for aneurysm coil embolization and C3 and C4 complement values from this serum were compared with complement values in the parent artery. Ten patients were enrolled over 32 months with a mean aneurysm size of 9.1 mm. Compared to control samples drawn from peripheral circulation, there were significant decreases of both C3 ( = 0.0003) and C4 ( = 0.0063) levels in aneurysmal blood samples. A state of decreased complement indicative of classic pathway activation was found in all tested aneurysms, thus providing evidence of an ongoing process of complement activation in the blood of live, unruptured aneurysm sacs.
颅内动脉瘤的生长及最终破裂可能归因于潜在的炎症过程，这一点已通过动脉瘤壁的病理检查得到证实。我们推测，与脑动脉血管系统的其他部分相比，未破裂动脉瘤腔内的炎症环境有所增加。对因动脉瘤弹簧圈栓塞前来就诊患者的未破裂动脉瘤进行采血，并将该血清中的C3和C4补体值与母动脉中的补体值进行比较。在32个月内招募了10名患者，动脉瘤平均大小为9.1毫米。与从外周循环采集的对照样本相比，动脉瘤血样中的C3（P = 0.0003）和C4（P = 0.0063）水平均显著降低。在所有测试的动脉瘤中均发现补体降低的状态，表明经典途径被激活，从而为活的未破裂动脉瘤囊血液中正在进行的补体激活过程提供了证据。
