白细胞介素-22 在肺部感染期间维持上皮完整性中起着关键作用。
IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection.
机构信息
Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
出版信息
Front Immunol. 2020 Jun 9;11:1160. doi: 10.3389/fimmu.2020.01160. eCollection 2020.
Abstract
Pulmonary infection is a leading cause of hospitalization in world. Lung damage due to infection and host mediated pathology can have life threatening consequences. Factors that limit lung injury and/or promote epithelial barrier function and repair are highly desirable as immunomodulatory therapeutics. Over the last decade, interleukin-22 has been shown to have pulmonary epithelial protective functions at the mucosal immune interface with bacterial and viral pathogens. This article summarizes recent findings in this area and provides perspective regarding the role of IL-22 in mucosal host defense.
摘要
肺部感染是导致全球住院的主要原因。感染和宿主介导的病理导致的肺部损伤可能会产生危及生命的后果。因此，作为免疫调节治疗方法，能够限制肺部损伤和/或促进上皮屏障功能和修复的因素是非常需要的。在过去十年中，白细胞介素-22 已被证明在与细菌和病毒病原体的黏膜免疫界面具有肺上皮保护功能。本文总结了这一领域的最新发现，并就白细胞介素-22 在黏膜宿主防御中的作用提供了一些观点。
相似文献
1
IL-22 Plays a Critical Role in Maintaining Epithelial Integrity During Pulmonary Infection.白细胞介素-22 在肺部感染期间维持上皮完整性中起着关键作用。
Front Immunol. 2020 Jun 9;11:1160. doi: 10.3389/fimmu.2020.01160. eCollection 2020.
2
Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier.IL-10RB 相关细胞因子、IL-22 和 IFN-λ 参与气道黏膜屏障防御。
Front Cell Infect Microbiol. 2020 Jun 19;10:300. doi: 10.3389/fcimb.2020.00300. eCollection 2020.
3
Using Lung Organoids to Investigate Epithelial Barrier Complexity and IL-17 Signaling During Respiratory Infection.利用肺类器官研究呼吸道感染期间上皮屏障的复杂性和白细胞介素-17信号传导
Front Immunol. 2019 Feb 28;10:323. doi: 10.3389/fimmu.2019.00323. eCollection 2019.
4
Mechanisms of Epithelial Immunity Evasion by Respiratory Bacterial Pathogens.呼吸道细菌病原体逃避上皮免疫的机制。
Front Immunol. 2020 Feb 11;11:91. doi: 10.3389/fimmu.2020.00091. eCollection 2020.
5
Susceptibility to viral infections in chronic obstructive pulmonary disease: role of epithelial cells.慢性阻塞性肺疾病对病毒感染的易感性：上皮细胞的作用。
Curr Opin Pulm Med. 2013 Mar;19(2):125-32. doi: 10.1097/MCP.0b013e32835cef10.
6
Bacterial infection and the pathogenesis of COPD.细菌感染与慢性阻塞性肺疾病的发病机制
Chest. 2000 May;117(5 Suppl 1):286S-91S. doi: 10.1378/chest.117.5_suppl_1.286s.
7
Innate immunity in the lung: how epithelial cells fight against respiratory pathogens.肺部的固有免疫：上皮细胞如何对抗呼吸道病原体。
Eur Respir J. 2004 Feb;23(2):327-33. doi: 10.1183/09031936.03.00098803.
8
Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients.气道中白细胞介素-22 通路在囊性纤维化患者中的失活。
Cytokine. 2019 Jan;113:470-474. doi: 10.1016/j.cyto.2018.10.015. Epub 2018 Oct 28.
9
Lung epithelial NOX/DUOX and respiratory virus infections.肺上皮细胞中的NADPH氧化酶/双氧化酶与呼吸道病毒感染
Clin Sci (Lond). 2015 Mar;128(6):337-47. doi: 10.1042/CS20140321.
10
IL-22: An Underestimated Player in Natural Resistance to Tuberculosis?IL-22：在天然抵抗结核病方面被低估的角色？
Front Immunol. 2018 Sep 25;9:2209. doi: 10.3389/fimmu.2018.02209. eCollection 2018.
引用本文的文献
1
Development of a bivalent protein subunit vaccine against infection by Pseudomonas aeruginosa and Staphylococcus aureus.一种针对铜绿假单胞菌和金黄色葡萄球菌感染的二价蛋白亚单位疫苗的研发。
NPJ Vaccines. 2025 Jul 25;10(1):169. doi: 10.1038/s41541-025-01220-y.
2
Protection of infant mice against pertussis, tuberculosis and influenza by co-administration of nasal pertussis vaccine candidate BPZE1 and BCG.通过联合鼻内给予百日咳疫苗候选株BPZE1和卡介苗（BCG）对幼鼠进行百日咳、结核病和流感的防护。
iScience. 2025 Jun 7;28(7):112839. doi: 10.1016/j.isci.2025.112839. eCollection 2025 Jul 18.
3
Profiling of human IL-22+ T cell clones from patients affected with Schistosoma mansoni: Insights into macrophage regulation and liver fibrosis.来自曼氏血吸虫病患者的人IL-22 + T细胞克隆分析：对巨噬细胞调节和肝纤维化的见解
PLoS Negl Trop Dis. 2025 May 30;19(5):e0013132. doi: 10.1371/journal.pntd.0013132. eCollection 2025 May.
4
Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model.阿司匹林触发的消退素D1在白细胞介素-22基因敲除的有机粉尘暴露小鼠模型中调节肺部和神经炎症。
Front Immunol. 2024 Dec 17;15:1495581. doi: 10.3389/fimmu.2024.1495581. eCollection 2024.
5
Alleviates Hyperoxia-Induced BPD by Activating IL-22/STAT3 Signaling Pathway in Neonatal Mice.通过激活新生小鼠的IL-22/STAT3信号通路减轻高氧诱导的支气管肺发育不良
Mediators Inflamm. 2024 Dec 9;2024:4965271. doi: 10.1155/mi/4965271. eCollection 2024.
6
IL-22 and IL-23 regulate the anticryptococcal response during infection.白细胞介素-22和白细胞介素-23在感染期间调节抗隐球菌反应。
iScience. 2024 Sep 27;27(10):111054. doi: 10.1016/j.isci.2024.111054. eCollection 2024 Oct 18.
7
Extra-pulmonary control of respiratory defense.肺外对呼吸防御的控制。
Cell Immunol. 2024 Jul-Aug;401-402:104841. doi: 10.1016/j.cellimm.2024.104841. Epub 2024 Jun 7.
8
Ex Pluribus Unum: The CD4 T Cell Response against Influenza A Virus.从多到一：针对甲型流感病毒的 CD4 T 细胞反应。
Cells. 2024 Apr 5;13(7):639. doi: 10.3390/cells13070639.
9
The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review.肠道微生物群在自身免疫性肝炎发病机制中的意义：叙述性综述。
Front Cell Infect Microbiol. 2024 Feb 9;14:1337223. doi: 10.3389/fcimb.2024.1337223. eCollection 2024.
10
Interleukin-22 Contributes to Blood-Brain Barrier Disruption via STAT3/VEGFA Activation in Meningitis.白细胞介素-22 通过 STAT3/VEGFA 激活促进脑膜炎血脑屏障破坏。
ACS Infect Dis. 2024 Mar 8;10(3):988-999. doi: 10.1021/acsinfecdis.3c00668. Epub 2024 Feb 6.
本文引用的文献
1
COVID-19: Immunology and treatment options.新型冠状病毒肺炎：免疫学与治疗选择。
Clin Immunol. 2020 Jun;215:108448. doi: 10.1016/j.clim.2020.108448. Epub 2020 Apr 27.
2
COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.COVID-19 与心血管系统：对风险评估、诊断和治疗选择的影响。
Cardiovasc Res. 2020 Aug 1;116(10):1666-1687. doi: 10.1093/cvr/cvaa106.
3
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19).关于2019年大流行性冠状病毒病（COVID-19）临床表现及管理的综合文献综述
Cureus. 2020 Apr 6;12(4):e7560. doi: 10.7759/cureus.7560.
4
Interleukin-22 regulates interferon lambda expression in a mice model of pseudomonas aeruginosa pneumonia.白细胞介素-22 在铜绿假单胞菌肺炎小鼠模型中调节干扰素 lambda 的表达。
Mol Immunol. 2020 Feb;118:52-59. doi: 10.1016/j.molimm.2019.12.003. Epub 2019 Dec 16.
5
Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection.靶向 IL-22/IL-22BP 轴可增强流感感染期间的紧密连接并减少炎症。
Mucosal Immunol. 2020 Jan;13(1):64-74. doi: 10.1038/s41385-019-0206-9. Epub 2019 Oct 9.
6
Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia.白细胞介素-22（IL-22）结合蛋白在肺炎链球菌性肺炎期间限制 IL-22 的活性、宿主防御和氧化磷酸化基因。
Infect Immun. 2019 Oct 18;87(11). doi: 10.1128/IAI.00550-19. Print 2019 Nov.
7
IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1.IL-22Ra1 在流感感染期间通过直接和间接 TLR3 诱导 STAT1 而诱导产生。
Respir Res. 2019 Aug 15;20(1):184. doi: 10.1186/s12931-019-1153-4.
8
IL-22-binding protein exacerbates influenza, bacterial super-infection.白细胞介素 22 结合蛋白加剧流感、细菌合并感染。
Mucosal Immunol. 2019 Sep;12(5):1231-1243. doi: 10.1038/s41385-019-0188-7. Epub 2019 Jul 11.
9
Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection.干扰素 λ 抑制流感病毒再感染期间的细菌摄取。
Infect Immun. 2019 Apr 23;87(5). doi: 10.1128/IAI.00114-19. Print 2019 Mar.
10
Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients.气道中白细胞介素-22 通路在囊性纤维化患者中的失活。
Cytokine. 2019 Jan;113:470-474. doi: 10.1016/j.cyto.2018.10.015. Epub 2018 Oct 28.
Zotero 插件