Wells Mike, Goldstein Lara N
Emergency Medicine, University of the Witwatersrand, Johannesburg, ZAF.
Cureus. 2020 May 22;12(5):e8232. doi: 10.7759/cureus.8232.
Background In obese children, lipophilic medications should be dosed to total body weight (TBW) and hydrophilic medications to ideal body weight (IBW). During emergencies, these weights need to be estimated to ensure that urgent drug therapy is accurate and safe. The Mercy method is a well-established weight estimation system that has recently been adapted to provide estimations of body length in children. It was therefore conceivable that this could be further modified to provide estimations of IBW. Methods A model was developed a priori using the Mercy method's humeral length (HL) segments to predict IBW. The accuracy of this model was then tested in a sample of 13,134 children from the National Health and Nutrition Examination Survey (NHANES) datasets. The accuracy of IBW estimation was determined from the percentage of estimations falling within 10% (p10) and 20% (p20) of true IBW. The model was also tested to see the accuracy of the detection of obesity in the study sample. Results From the sample of 13,134 children, a subset of 1,318 obese children were identified. In this subset, the new Mercy method model achieved an IBW estimation accuracy p10 of 66.9% and a p20 of 95.1%. For the detection of the obese child, the model had a sensitivity of 88.6% and a specificity of 75.8%. Conclusions This study established that the Mercy method can be modified to provide a reasonably accurate estimation of IBW in obese children, with very few critical errors. The ability of the model to identify the obese child was also reasonably accurate, on a par with other such predictive methods. While other accurate methods of estimating both TBW and IBW exist, such as the Paediatric Advanced Weight Prediction in the Emergency Room eXtra-Long tape (PAWPER XL tape), the modified Mercy method is an acceptable alternative if such other devices are not available.
背景 在肥胖儿童中,亲脂性药物应以总体重(TBW)给药,亲水性药物应以理想体重(IBW)给药。在紧急情况下,需要估算这些体重以确保紧急药物治疗的准确性和安全性。梅西方法是一种成熟的体重估算系统,最近已被改编用于估算儿童的身长。因此,可以设想对其进行进一步修改以提供理想体重的估算。方法 使用梅西方法的肱骨长度(HL)段先验开发一个模型来预测理想体重。然后在来自国家健康与营养检查调查(NHANES)数据集的13134名儿童样本中测试该模型的准确性。理想体重估算的准确性由落在真实理想体重的10%(p10)和20%(p20)范围内的估算百分比确定。还测试了该模型在研究样本中检测肥胖的准确性。结果 在13134名儿童样本中,识别出1318名肥胖儿童的子集。在这个子集中,新的梅西方法模型实现了理想体重估算准确性p10为66.9%,p20为95.1%。对于肥胖儿童的检测,该模型的灵敏度为88.6%,特异性为75.8%。结论 本研究确定,梅西方法可以修改以在肥胖儿童中提供相当准确的理想体重估算,关键误差极少。该模型识别肥胖儿童的能力也相当准确,与其他此类预测方法相当。虽然存在其他准确估算总体重和理想体重的方法,如急诊室超长卷尺中的儿科高级体重预测(PAWPER XL卷尺),但如果没有此类其他设备,改良的梅西方法是一个可接受的替代方法。