Rantapää Dahlqvist S, Beckman G, Beckman L
Department of Medical Genetics, University of Umeå, Sweden.
Hum Hered. 1988;38(1):44-7. doi: 10.1159/000153753.
Serum protein markers (alpha 1-AT, Bf, C3, C4A, C4B, Hp and Tf) were studied in a series of 36 patients with systemic lupus erythematosus (SLE) and compared to normal blood donors. In agreement with the results of previous investigations a significant increase of complement C4 deficiency was found among the SLE patients. The relative risks for AQ0 and BQ0 homozygosity were 7.2 and 4.1, respectively. Simultaneous occurrence of AQ0 and BQ0 was found in three patients with a calculated relative risk of about 65. A significant increase of the haptoglobin type 2-2 (p less than 0.05) was found among SLE patients. The remaining serum protein systems showed no statistically significant associations with SLE.
对36例系统性红斑狼疮（SLE）患者的血清蛋白标志物（α1-抗胰蛋白酶、B因子、C3、C4A、C4B、触珠蛋白和转铁蛋白）进行了研究，并与正常献血者进行了比较。与先前的研究结果一致，在SLE患者中发现补体C4缺乏显著增加。AQ0和BQ0纯合子的相对风险分别为7.2和4.1。在3例患者中发现AQ0和BQ0同时出现，计算出的相对风险约为65。在SLE患者中发现触珠蛋白2-2型显著增加（p<0.05）。其余血清蛋白系统与SLE无统计学显著关联。
