Luo Jing, Beam Christopher R, Karlsson Ida K, Pike Christian J, Reynolds Chandra A, Gatz Margaret
Department of Psychology University of Southern California Los Angeles California USA.
Leonard Davis School of Gerontology University of Southern California Los Angeles California USA.
Alzheimers Dement (Amst). 2020 Jun 21;12(1):e12049. doi: 10.1002/dad2.12049. eCollection 2020.
Hormones may be one possible mechanism underlying sex differences in dementia incidence. We examined whether presumed differential prenatal hormone milieu is related to dementia risk by comparing dementia rates in same- and opposite-sex dizygotic twin pairs in male and female twins.
The sample comprised 43,254 individuals from dizygotic twin pairs aged 60 and older from the Swedish Twin Registry. Survival analyses were conducted separately for females and males.
Female twins from opposite-sex pairs had significantly lower dementia risk than female twins from same-sex pairs, but the differences emerged only after age 70 (hazard ratio = 0.64, = 0.004). Results were not explained by postnatal risk factors for dementia, and no interaction between twin type and apolipoprotein E () was found. Male twins from same-sex versus opposite-sex pairs did not differ significantly.
The results suggest that relatively masculine prenatal hormone milieus correlate with lower dementia risk in females.
激素可能是痴呆症发病率存在性别差异的一种潜在机制。我们通过比较同性和异性双卵双胞胎对中男性和女性双胞胎的痴呆症发病率，研究了假定的不同产前激素环境是否与痴呆症风险相关。
样本包括来自瑞典双胞胎登记处的43254名60岁及以上双卵双胞胎对中的个体。分别对女性和男性进行生存分析。
异性双胞胎对中的女性双胞胎患痴呆症的风险明显低于同性双胞胎对中的女性双胞胎，但这种差异仅在70岁以后出现（风险比 = 0.64， = 0.004）。结果无法用痴呆症的产后风险因素来解释，并且未发现双胞胎类型与载脂蛋白E（）之间存在相互作用。同性与异性双胞胎对中的男性双胞胎没有显著差异。
结果表明，相对男性化的产前激素环境与女性较低的痴呆症风险相关。
