刺激响应的环金化“关-开”型阴离子转运体。
Stimuli-Responsive Cycloaurated "OFF-ON" Switchable Anion Transporters.
机构信息
School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006, Australia.
School of Chemistry & Molecular Bioscience, Molecular Horizons, University of Wollongong, Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia.
出版信息
Angew Chem Int Ed Engl. 2020 Sep 28;59(40):17614-17621. doi: 10.1002/anie.202006392. Epub 2020 Aug 11.
Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are "switched on" in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.
阴离子转运体作为抗癌药物具有潜在的应用前景，其作用机制是破坏内稳态并引发细胞死亡。在本研究论文中，我们报告了阴离子转运体的金配合物的可切换阴离子转运，该配合物在还原剂 GSH 的存在下通过金的去络合而“原位”开启。GSH 在肿瘤中的浓度高于健康组织，因此这种方法为将这些系统靶向肿瘤提供了一种策略。
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