Department of Obstetrics and Gynecology, Saint Luke's University, Bethlehem, PA.
Department of Obstetrics and Gynecology, University of California, San Francisco, San Francisco, CA.
Liver Transpl. 2020 Oct;26(10):1233-1240. doi: 10.1002/lt.25835. Epub 2020 Sep 5.
Fertility is often impaired in adolescents and women with cirrhosis, but it is rapidly restored after liver transplantation (LT). Early and unplanned pregnancies confer increased risks to maternal, fetal, and graft health, underscoring the need for reproductive counseling. However, data on reproductive practices or counseling in the LT setting are limited. An anonymous online Qualtrics (Provo, UT) survey was sent to transplant patients and providers to gauge knowledge and practices surrounding contraception and pregnancy. Eligible participants included transplant patients aged 14-45 years and their transplant providers. Patient response was 50.0% (74/148), 14 of whom were pre-LT patients and 60 of whom were post-LT patients. Counseling occurred in 37% of patients prior to transplant and 82% after transplant. Most patients (86%) considered family planning a high priority in their transplant care. Contraception- and pregnancy-specific counseling was provided by LT providers in 60% and 44% of patients, respectively. The most desired mode of counseling by patients was in-person discussion with an LT provider (89%). Despite most post-LT patients receiving counseling, only 41% used contraception during the first year after LT, of whom 32% relied on high failure methods. Of the 31/43 (72.1%) provider responses, 96% voiced interest in additional reproductive education. Most providers (90%) correctly advised that patients delay pregnancy during the first year after LT, although misconceptions about safety of estrogen and intrauterine devices were selected by 53% and 42%, respectively. Some favored resources by providers were educational pamphlets in clinic (88%) and automated note templates to prompt family planning inquiry (72%). Transplant patients and providers have key deficiencies in their knowledge of contraception and corresponding practices. Most post-LT patients receive counseling, yet contraception practices are inadequate for preventing unplanned pregnancy. Discussion with transplant providers was the most favored counseling modality by patients, underscoring our critical role in optimizing post-LT reproductive care.
生育能力常受到青少年和肝硬化女性的损害,但在肝移植(LT)后迅速恢复。早期和无计划的妊娠会增加母婴、胎儿和移植物健康的风险,这凸显了生殖咨询的必要性。然而,LT 环境中关于生殖实践或咨询的数据有限。我们采用在线匿名的 Qualtrics(犹他州普罗沃)调查,向移植患者和提供者发送调查,以评估避孕和妊娠相关的知识和实践。合格的参与者包括年龄在 14-45 岁的移植患者及其移植提供者。患者的回复率为 50.0%(74/148),其中 14 名是 LT 前患者,60 名是 LT 后患者。37%的患者在 LT 前接受过咨询,82%的患者在 LT 后接受过咨询。大多数患者(86%)认为在移植护理中计划生育是重中之重。LT 提供者分别为 60%和 44%的患者提供了避孕和妊娠的具体咨询。患者最希望的咨询模式是与 LT 提供者进行面对面讨论(89%)。尽管大多数 LT 后患者接受了咨询,但只有 41%的患者在 LT 后第一年使用了避孕措施,其中 32%依赖高失败率的方法。在 31/43(72.1%)名提供者的回复中,96%的人对生殖教育表示感兴趣。大多数提供者(90%)正确建议患者在 LT 后第一年推迟怀孕,尽管 53%和 42%的人分别选择了关于雌激素和宫内节育器安全性的错误观念。一些提供者青睐的资源包括诊所中的教育小册子(88%)和自动提示生育计划查询的模板(72%)。移植患者和提供者在避孕知识和相应实践方面存在重大缺陷。大多数 LT 后患者接受咨询,但避孕措施不足以防止意外怀孕。与移植提供者的讨论是患者最青睐的咨询方式,凸显了我们在优化 LT 后生殖护理方面的关键作用。