Koskela P, Vaarala O, Mäkitalo R, Palosuo T, Aho K
National Public Health Institute, Helsinki, Finland.
J Rheumatol. 1988 Jan;15(1):70-3.
The highly sensitive rapid plasma reagin (RPR) and Treponema pallidum hemagglutination tests were used to determine the frequency of false positive syphilis reactions in a nationwide series of pregnant women in Finland. The frequency found was 14/10,000. Two cases of systemic lupus and 2 of undefined connective tissue disease were found during a 20-month period among 134 false positive reactors in a series of 110,000 separate pregnancies. The risk of subsequent fetal loss among false positive syphilis reactors was 7%, similar to the risk in RPR negative controls. Half of the sera in the highest RPR titer groups and 1/3 in the lowest titer groups had elevated levels of anticardiolipin antibodies in solid-phase enzyme immunoassay. This assay did not increase the risk of clinical disease or subsequent fetal loss above the risk of RPR test alone.
采用高灵敏度快速血浆反应素（RPR）和梅毒螺旋体血凝试验，来确定芬兰全国范围内一系列孕妇梅毒反应假阳性的发生率。所发现的发生率为14/10,000。在110,000例单独妊娠的一系列134例假阳性反应者中，在20个月期间发现了2例系统性红斑狼疮和2例未明确的结缔组织病。梅毒反应假阳性者随后发生胎儿丢失的风险为7%，与RPR阴性对照组的风险相似。在固相酶免疫测定中，RPR滴度最高组的一半血清和滴度最低组的1/3血清抗心磷脂抗体水平升高。该测定并未使临床疾病风险或随后胎儿丢失风险高于仅进行RPR检测的风险。
