Rimvall Martin K, Jeppesen Pia, Skovgaard Anne Mette, Verhulst Frank, Olsen Else Marie, Rask Charlotte Ulrikka
Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Child Psychol Psychiatry. 2021 Apr;62(4):441-448. doi: 10.1111/jcpp.13286. Epub 2020 Jun 25.
Severe health anxiety (HA) is characterized by excessive and impairing worry and preoccupation with health issues and can cause increased and unnecessary medical examinations. HA in childhood and adolescence is scarcely explored, hindering the potential for prevention and early intervention.
HA was assessed in 1,278 children/youths at two time points at ages 11 and 16 years in a general population-based birth cohort. Register-based data on costs related to nonhospital-based primary and secondary somatic health services were obtained over the follow-up period. The presence of functional somatic symptoms, emotional disorders and chronic somatic illness at baseline were included as covariates.
High HA (top 10% score) at age 11 predicted high HA at age 16 (relative risk [RR] 2.03, 95% CI: 1.26-3.31). The group with persistent HA was small (n = 17, 1.3%), resulting in broad confidence intervals. The statistical effect of HA at age 11 on HA at age 16 was heavily reduced after adjustment for sex and all covariates (RR: 1.49, 95% CI: 0.85-2.60). In the adjusted model, somatic illness at age 11 (RR: 1.91, 95% CI: 1.22-2.98) and female sex (RR: 3.33, 95% CI: 2.01-5.50) were independently associated with HA at age 16. Persistent HA was associated with approximately doubled healthcare costs compared to the group with consistently low HA. Incident HA at age 16 was associated with increased costs over follow-up. The increased costs were not explained by chronic somatic illness.
A small subgroup of children had persistent high levels of HA from late childhood to adolescence and displayed increased healthcare costs. Female sex and chronic somatic disorders at age 11 were independent risk factors of HA at age 16. These findings provide potential means of early identification and of therapeutic levers. Further intervention development and evaluation are needed.
严重健康焦虑(HA)的特征是对健康问题过度担忧且这种担忧妨碍日常生活,并可能导致进行更多不必要的医学检查。儿童期和青少年期的健康焦虑很少被研究,这阻碍了预防和早期干预的可能性。
在一个基于普通人群的出生队列中,对1278名儿童/青少年在11岁和16岁这两个时间点进行了健康焦虑评估。在随访期间,获取了基于登记的与非医院初级和二级躯体健康服务相关的费用数据。将基线时功能性躯体症状、情绪障碍和慢性躯体疾病的存在作为协变量纳入。
11岁时高健康焦虑(得分前10%)可预测16岁时高健康焦虑(相对风险[RR] 2.03,95%置信区间:1.26 - 3.31)。持续性健康焦虑组规模较小(n = 17,1.3%),导致置信区间较宽。在对性别和所有协变量进行调整后,11岁时健康焦虑对16岁时健康焦虑的统计效应大幅降低(RR:1.49,95%置信区间:0.85 - 2.60)。在调整模型中,11岁时的躯体疾病(RR:1.91,95%置信区间:1.22 - 2.98)和女性性别(RR:3.33,95%置信区间:2.01 - 5.50)与16岁时的健康焦虑独立相关。与持续低健康焦虑组相比,持续性健康焦虑与医疗费用增加约一倍相关。16岁时新发健康焦虑与随访期间费用增加相关。费用增加无法用慢性躯体疾病来解释。
一小部分儿童从童年晚期到青少年期持续存在高水平的健康焦虑,并表现出医疗费用增加。女性性别和11岁时的慢性躯体疾病是16岁时健康焦虑的独立危险因素。这些发现提供了早期识别和治疗手段的潜在方法。需要进一步开展干预措施的开发和评估。