活体供肾肾移植后发生的伴有供者特异性抗HLA-DP抗体的慢性活动性抗体介导排斥反应：一例报告
Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti-HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report.
作者信息
Fukuoka Kengo, Tokodai Kazuaki, Miyagi Shigehito, Nakanishi Wataru, Nishimura Ryuichi, Fujio Atsushi, Watanabe Hirofumi, Taniuchi Shinji, Naitoh Takeshi, Ishida Takanori, Unno Michiaki, Kamei Takashi
机构信息
Department of Surgery, Tohoku University Hospital, Sendai, Miyagi, Japan.
Department of Surgery, Tohoku University Hospital, Sendai, Miyagi, Japan.
出版信息
Transplant Proc. 2020 Jul-Aug;52(6):1937-1939. doi: 10.1016/j.transproceed.2020.02.130. Epub 2020 Jun 23.
Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been well established and remain unclear. We report a case of living donor kidney transplantation. The level of serum creatinine gradually became elevated because of chronic active antibody-mediated rejection, which was considered to be caused by anti-DP DSA. In this report, we indicate the significance of pretransplant screening for HLA-DP in donors to evaluate more comprehensively the donor specificity of posttransplant HLA antibodies.
移植后供者特异性抗人白细胞抗原（HLA）抗体（DSA）可导致慢性抗体介导的排斥反应。尤其已表明，抗DR和抗DQ DSA与移植肾功能不良有关。相比之下，抗DP DSA的患病率及意义尚未得到充分证实，仍不明确。我们报告一例活体供肾移植病例。由于慢性活动性抗体介导的排斥反应，血清肌酐水平逐渐升高，该反应被认为是由抗DP DSA引起的。在本报告中，我们指出了对供者进行移植前HLA-DP筛查的意义，以便更全面地评估移植后HLA抗体的供者特异性。
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