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食管闭锁术后吻合口狭窄的危险因素及处理。

Risk factors and management for anastomotic stricture after surgical reconstruction of esophageal atresia.

机构信息

Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan; Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Pediatric Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.

出版信息

J Formos Med Assoc. 2021 Jan;120(1 Pt 2):404-410. doi: 10.1016/j.jfma.2020.06.020. Epub 2020 Jun 22.

Abstract

BACKGROUND/PURPOSE: Anastomotic stricture (AS) is a major morbidity of patients with esophageal atresia (EA) after surgical reconstruction. Our study determined the risk factors of AS after EA reconstruction. The therapeutic efficacy and complications of esophageal dilatation for children with AS were also evaluated.

METHODS

Forty children treated for EA between January 2008 and December 2018 were included in this retrospective analysis. Esophageal dilatation was performed when AS was diagnosed. The therapeutic effect of esophageal dilatation was determined based on nutritional status, as assessed by the weight-for-age z-score.

RESULTS

Sixteen EA patients developed AS. A gap >1.5 cm between the esophageal pouches (P = 0.02) in patients with EA and type A EA was a risk factor for developing AS. A mean of 7.7 sessions of esophageal dilatation were performed per patient, and no complications occurred. The nutritional status of EA children with AS after dilatation was not inferior to that of the children without AS at the 6-month follow-up.

CONCLUSION

A gap >1.5 cm between the esophageal pouches and type A EA are risk factors for AS after esophageal reconstruction. Esophageal dilatation is both safe and effective for managing strictures and improves nutritional status in EA children with AS.

摘要

背景/目的:食管闭锁(EA)术后吻合口狭窄(AS)是患者的主要发病率。本研究旨在确定 EA 重建后 AS 的危险因素,并评估食管扩张术治疗 EA 后 AS 儿童的疗效和并发症。

方法

回顾性分析了 2008 年 1 月至 2018 年 12 月期间接受 EA 治疗的 40 例患儿。当诊断出 AS 时,进行食管扩张术。根据体重-年龄 z 评分评估营养状况来确定食管扩张术的治疗效果。

结果

16 例 EA 患儿出现 AS。EA 患儿食管囊之间的间隙>1.5cm(P=0.02)和 EA 型是发生 AS 的危险因素。每位患者平均进行了 7.7 次食管扩张术,没有发生并发症。扩张后,AS 患儿的营养状况与无 AS 患儿在 6 个月随访时无差异。

结论

食管囊之间的间隙>1.5cm 和 EA 型是食管重建后发生 AS 的危险因素。食管扩张术治疗 EA 后 AS 狭窄安全有效,可改善 AS 患儿的营养状况。

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