Yang Xuejing, Mei Jie, Wang Huiyu, Gu Dingyi, Ding Junli, Liu Chaoying
Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, No. 299 Qingyang Road, Wuxi, 214023 China.
Cancer Cell Int. 2020 Jun 23;20:265. doi: 10.1186/s12935-020-01367-9. eCollection 2020.
Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess several specific molecular functions, including regulating gene transcription and translation, acting as miRNA sponges, and interacting with functional proteins. Ovarian cancer (OvCa) is one of the most aggressive malignant diseases affecting the lives of thousands of women worldwide, and the majority of OvCa cases are diagnosed at advanced stages. Accumulating evidence has revealed the significant roles of circRNAs in the occurrence and progression of OvCa, indicating the function of circRNAs as promising biomarkers and their therapeutic relevance in this disease. This review aims to summarize the mechanisms by which circRNAs mediate OvCa progression as well as their diagnostic and prognostic values in OvCa.
环状RNA（circRNA）是一类新型的具有独特共价闭合环状结构的调控性非编码RNA（ncRNA）分子。新一代测序显示，数千种circRNA在多种真核生物中广泛且稳定地表达。作为新型调控性ncRNA，circRNA具有多种特定分子功能，包括调控基因转录和翻译、充当微小RNA（miRNA）海绵以及与功能蛋白相互作用。卵巢癌（OvCa）是影响全球数千名女性生命的最具侵袭性的恶性疾病之一，大多数卵巢癌病例在晚期被诊断出来。越来越多的证据表明circRNA在卵巢癌的发生和发展中起重要作用，这表明circRNA作为有前景的生物标志物的功能及其在该疾病中的治疗相关性。本综述旨在总结circRNA介导卵巢癌进展的机制及其在卵巢癌中的诊断和预后价值。
