Giftochristos N, David S
Department of Neurology, Montreal General Hospital Research Institute, McGill University, Que., Canada.
Brain Res. 1988 Mar 1;467(1):149-53. doi: 10.1016/0165-3806(88)90077-6.
The ability of immature central nervous system (CNS) glia to promote axonal regeneration was studied by grafting segments of embryonic and neonatal rat optic nerves into the sciatic nerves of adult rats. Unexpectedly, very few axons regenerated through these grafts. The majority of the axons bypassed the grafts and were associated with Schwann cells. These results were similar to those obtained with grafts of adult rat optic nerves. The failure of immature CNS glia to promote axonal regeneration under these conditions suggests that they may be less effective than Schwann cells in promoting the regeneration and growth of axons.
通过将胚胎和新生大鼠的视神经节段移植到成年大鼠的坐骨神经中，研究了未成熟中枢神经系统（CNS）神经胶质促进轴突再生的能力。出乎意料的是，很少有轴突通过这些移植段再生。大多数轴突绕过移植段，并与施万细胞相关联。这些结果与成年大鼠视神经移植的结果相似。在这些条件下，未成熟的中枢神经系统神经胶质未能促进轴突再生，这表明它们在促进轴突再生和生长方面可能不如施万细胞有效。
