Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Immunol Res. 2020 Jun 5;2020:3709749. doi: 10.1155/2020/3709749. eCollection 2020.
Psoriasis is a common inflammatory disease that can involve the skin, joints, or both. The abnormalities of innate immunity play crucial roles in the pathogenesis of psoriasis. Neutrophils are the most abundant leukocytes in the circulation. Emerging evidences have demonstrated that neutrophils may play a role in autoimmune diseases. The neutrophil-to-lymphocyte ratio (NLR), the activity of neutrophils, and the number of NETotic cells were significantly higher in psoriasis patients compared to healthy controls. The number of low-density granulocytes (LDGs) in the blood of psoriasis patients was significantly higher than those in the control blood. Furthermore, neutrophils may play important roles in the cardiovascular risk in psoriasis. However, the exact role of neutrophils in psoriasis remains unclear. In this review, we highlight the role of neutrophils in the pathogenesis of psoriasis.
银屑病是一种常见的炎症性疾病，可累及皮肤、关节或两者兼有。固有免疫异常在银屑病的发病机制中起着关键作用。中性粒细胞是循环中最丰富的白细胞。新出现的证据表明，中性粒细胞可能在自身免疫性疾病中发挥作用。与健康对照组相比，银屑病患者的中性粒细胞与淋巴细胞比值（NLR）、中性粒细胞活性和 NETotic 细胞数量明显更高。银屑病患者血液中的低密度粒细胞（LDG）数量明显高于对照组。此外，中性粒细胞可能在银屑病的心血管风险中发挥重要作用。然而，中性粒细胞在银屑病中的确切作用尚不清楚。在这篇综述中，我们强调了中性粒细胞在银屑病发病机制中的作用。
