寻常型银屑病患者单核细胞与高密度脂蛋白比值与弗雷明汉风险评分的关联及作为心血管风险预测指标的研究

Association of the Monocyte-to-High Density Lipoprotein Ratio with the FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis Vulgaris.

作者信息

Gu Xueqin, Shen Hongmei, Jiang Jiafeng, Gu Ping, Liu Peilong, Zhao Zhenguo, Ge Jinfang

机构信息

Department of Dermatology, The Second People's Hospital of Nantong, Nantong, Jiangsu Province, People's Republic of China.

Department of Clinical Laboratory, The Second People's Hospital of Nantong, Nantong, Jiangsu Province, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2025 May 1;18:1051-1062. doi: 10.2147/CCID.S518521. eCollection 2025.

DOI:10.2147/CCID.S518521

PMID:40329961

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12053381/

Abstract

OBJECTIVE

The monocyte-to-high-density lipoprotein ratio (MHR) has emerged as a novel inflammatory biomarker associated with cardiovascular diseases (CVDs). This retrospective study aimed to investigate the relationship between MHR and the Framingham risk score (FRS) and assess the prognostic significance of this relationship for mid- to high-risk CVD in individuals with psoriasis vulgaris (PsV).

METHODS

A total of 128 PsV patients and 120 healthy controls were included. The neutrophil-to-high-density lipoprotein ratio (NHR), MHR, and neutrophil-to-lymphocyte ratio (NLR) were assessed and compared between the two groups. Correlations between MHR and FRS were evaluated.

RESULTS

PsV patients with intermediate to high cardiovascular risk exhibited significantly higher NHR, MHR, and NLR compared to controls (p = 0.018, p = 0.002, p < 0.001, respectively). Furthermore, FRS was positively correlated with MHR, NHR, and NLR in the PsV patients (r=0.27, p = 0.002; r=0.21, p = 0.017 and r=0.33, p < 0.001, respectively). Logistic regression analysis identified age, sex, and the MHR as influencing factors for the FRS (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed that the highest Youden's index (0.316) was obtained at an MHR of 0.24, with sensitivity, specificity, and area under the ROC curve of 0.729, 0.587, and 0.662 (95% CI of 0.565, 0.758), respectively.

CONCLUSION

MHR was significantly associated with FRS, which may serve as a valuable predictor of medium to high risk of CVDs in patients with PsV.

摘要

目的

单核细胞与高密度脂蛋白比值（MHR）已成为一种与心血管疾病（CVD）相关的新型炎症生物标志物。这项回顾性研究旨在探讨MHR与弗雷明汉风险评分（FRS）之间的关系，并评估这种关系对寻常型银屑病（PsV）患者中高危CVD的预后意义。

方法

共纳入128例PsV患者和120例健康对照。评估并比较两组的中性粒细胞与高密度脂蛋白比值（NHR）、MHR和中性粒细胞与淋巴细胞比值（NLR）。评估MHR与FRS之间的相关性。

结果

心血管风险为中到高的PsV患者与对照组相比，NHR、MHR和NLR显著更高（分别为p = 0.018、p = 0.002、p < 0.001）。此外，PsV患者中FRS与MHR、NHR和NLR呈正相关（分别为r = 0.27，p = 0.002；r = 0.21，p = 0.017；r = 0.33，p < 0.001）。逻辑回归分析确定年龄、性别和MHR为FRS的影响因素（p < 0.05）。受试者工作特征（ROC）曲线分析显示，MHR为0.24时约登指数最高（0.316），ROC曲线下面积、敏感度和特异度分别为0.662（95%CI为0.565, 0.758）、0.729和0.587。