Alagöz Ali, Küçükgüçlü Semih, Boztaş Nilay, Hancı Volkan, Yuluğ Esin, Şişman Ali Rıza
Department of Anesthesiology, Foca State Hospital, İzmir-Turkey.
Department of Anesthesiology and Reanimation, Dokuz Eylül University Faculty of Medicine, İzmir-Turkey.
Ulus Travma Acil Cerrahi Derg. 2020 Jul;26(4):509-516. doi: 10.14744/tjtes.2019.12524.
The hypothesis of our study is that sugammadex has protective efficacy against ischemia-reperfusion (I/R) injury in rats.
Our study included 28 male Wistar Albino rats. The rats were assigned to four groups. The sham group had no procedure other than anesthesia administration. The control group received three hours of ischemia and 24 hours of reperfusion. The Sgdx4 group received 4 mg/kg, and the Sgdx16 group received 16 mg/kg sugammadex intravenously, and then, reperfusion was applied. Histopathological investigation, and serum creatine kinase (CK), lactate dehydrogenase (LDH), and serum and tissue malondialdehyde (MDA) and superoxide dismutase (SOD) analyses were performed.
When the sham group and the control group were compared, there were statistically significant differences histopathologically (p<0.01). There was no significant difference between the Sgdx4 group compared with the sham and control groups histopathologically (p>0.01). There was a significant difference between the Sgdx16 group and the sham group histopathologically (p<0.01). There were significant differences between the sham and control groups concerning CK and LDH levels (p<0.01). There was a significant difference in the levels of CK between the control group and Sgdx4 group and in the levels of CK and LDH between the control group and Sgdx16 group (p<0.01).
In our study, we examined the histological and biochemical protective effects of 4 mg/kg sugammadex on unilateral lower extremity I/R injury in rats. The findings suggest that a 4 mg/kg dose of sugammadex was more effective than a 16 mg/kg dose.
我们研究的假设是舒更葡糖钠对大鼠缺血再灌注（I/R）损伤具有保护作用。
我们的研究纳入了28只雄性Wistar白化大鼠。将大鼠分为四组。假手术组除给予麻醉外未进行其他操作。对照组经历3小时缺血和24小时再灌注。Sgdx4组静脉注射4mg/kg舒更葡糖钠，Sgdx16组静脉注射16mg/kg舒更葡糖钠，然后进行再灌注。进行了组织病理学检查以及血清肌酸激酶（CK）、乳酸脱氢酶（LDH）、血清和组织丙二醛（MDA）以及超氧化物歧化酶（SOD）分析。
当比较假手术组和对照组时，组织病理学上存在统计学显著差异（p<0.01）。Sgdx4组与假手术组和对照组相比，组织病理学上无显著差异（p>0.01）。Sgdx16组与假手术组在组织病理学上存在显著差异（p<0.01）。假手术组和对照组在CK和LDH水平上存在显著差异（p<0.01）。对照组和Sgdx4组之间的CK水平以及对照组和Sgdx16组之间的CK和LDH水平存在显著差异（p<0.01）。
在我们的研究中，我们研究了4mg/kg舒更葡糖钠对大鼠单侧下肢I/R损伤的组织学和生化保护作用。研究结果表明，4mg/kg剂量的舒更葡糖钠比16mg/kg剂量更有效。
