Can Osman, Özbir Sait, Atalay Hasan Anil, Çakır Süleyman Sami, Culha Mehmet Gökhan, Canat Halil Lütfi
Department of Urology, Basaksehir City Hospital, Istanbul, Turkey.
Department of Urology, Cemil Taşcıoglu City Hospital, Istanbul, Turkey.
Andrologia. 2020 Oct;52(9):e13727. doi: 10.1111/and.13727. Epub 2020 Jun 26.
Aetiologic and predisposing factors are still controversial about Peyronie's disease (PD). However, it is thought to be the result of connective tissue disorder or healing defect. Androgens are known to affect collagen metabolism and wound healing in the body. The aim of this study was to investigate the relationship between PD and low testosterone levels. One hundred and forty-seven Peyronie patients and 137 healthy volunteers were included in the study. In both groups, demographic data, medical history, physical examination and erectile capacity were recorded. Blood samples were collected from all subjects in the early morning hours after an overnight fast. The mean level of serum total testosterone was lower in men with PD compared with the controls (3.9 ± 1.1 vs. 4.2 ± 1.7 ng/ml respectively) (p = .062). However, statistically significant relationship was not found between PD and low serum testosterone levels. There was no significant correlation between penile plaque dimension or penile curvature degree and testosterone levels. Large randomised-controlled prospective studies are needed to reveal this possible association.
佩罗尼氏病（PD）的病因和诱发因素仍存在争议。然而，人们认为它是结缔组织紊乱或愈合缺陷的结果。已知雄激素会影响体内的胶原蛋白代谢和伤口愈合。本研究的目的是调查PD与低睾酮水平之间的关系。该研究纳入了147名佩罗尼氏病患者和137名健康志愿者。两组均记录了人口统计学数据、病史、体格检查和勃起能力。在所有受试者禁食过夜后的清晨采集血样。与对照组相比，PD男性的血清总睾酮平均水平较低（分别为3.9±1.1 vs. 4.2±1.7 ng/ml）（p = 0.062）。然而，未发现PD与低血清睾酮水平之间存在统计学上的显著关系。阴茎斑块大小或阴茎弯曲程度与睾酮水平之间无显著相关性。需要进行大规模随机对照前瞻性研究来揭示这种可能的关联。
