Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, P.R. China.
Department of Ophthalmology, Jinan Second People's Hospital, Jinan, P.R. China.
J Int Med Res. 2020 Jun;48(6):300060520926411. doi: 10.1177/0300060520926411.
To evaluate the clinical efficacy of corneal collagen cross-linking (CXL) in the treatment of infectious corneal diseases.
This study retrospectively analyzed the clinical efficacy of CXL in 65 eyes with infectious keratitis in Jinan Second People's Hospital from December 2016 to June 2018. During 6 months of follow-up after CXL treatment, the results of confocal microscopy and anterior segment optical coherence tomography, as well as visual acuity and corneal biomechanical parameters, were recorded in detail.
In general, the overall cure rate was 93.85%; no corneal endothelial dysfunction was encountered in any patients. After 6 months of follow-up, the visual acuity of cured patients was significantly enhanced, while corneal thickness was significantly reduced. Hyphae growth of patients with fungal keratitis was completely inhibited at 1 month postoperatively. Furthermore, corneal biomechanical parameters (i.e., central corneal thickness, deformation amplitude, and pachymetry intraocular pressure) were significantly improved after surgery, compared with baseline measurements.
Accelerated CXL may be an effective adjuvant treatment for infectious keratitis.
评估角膜胶原交联（CXL）治疗感染性角膜疾病的临床疗效。
本研究回顾性分析了 2016 年 12 月至 2018 年 6 月济南市第二人民医院 65 例感染性角膜炎患者行 CXL 的临床疗效。在 CXL 治疗后 6 个月的随访期间，详细记录共焦显微镜和眼前段光学相干断层扫描以及视力和角膜生物力学参数的结果。
总体治愈率为 93.85%；未发生任何患者的角膜内皮功能障碍。随访 6 个月后，治愈患者的视力明显提高，而角膜厚度明显降低。真菌性角膜炎患者的菌丝生长在术后 1 个月完全被抑制。此外，与基线测量值相比，术后角膜生物力学参数（即中央角膜厚度、变形幅度和眼压眼内压）显著改善。
加速 CXL 可能是治疗感染性角膜炎的有效辅助治疗方法。
