盖帽抢夺导致新型病毒蛋白产生。

Cap-Snatching Leads to Novel Viral Proteins.

机构信息

Division of Biology, University of California, San Diego, San Diego, CA, USA.

出版信息

Cell. 2020 Jun 25;181(7):1450-1451. doi: 10.1016/j.cell.2020.05.044.

DOI:10.1016/j.cell.2020.05.044

Abstract

Some negative-sense RNA viruses prime mRNA transcription using host 5' cap sequences, usurping host translational machinery and evading antiviral surveillance. In this issue of Cell, Ho et al. identify an additional consequence of this viral strategy: the acquisition of upstream start codons from host-derived sequences and subsequent translation of novel viral products.

摘要

一些负义 RNA 病毒使用宿主 5' 帽序列启动 mRNA 转录，篡夺宿主翻译机制并逃避抗病毒监测。在本期《细胞》中，Ho 等人发现了这种病毒策略的另一个后果：从宿主衍生序列获得上游起始密码子，并随后翻译新的病毒产物。