Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Hamburg, Germany.
European Molecular Biology Laboratory, Grenoble, France.
Trends Microbiol. 2020 Apr;28(4):293-303. doi: 10.1016/j.tim.2019.12.006. Epub 2020 Jan 13.
In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain heterologous sequences at their 5' termini originating from capped host cell RNAs. These heterologous sequences are acquired by a so-called cap-snatching mechanism. Whereas for nuclear replicating influenza virus the source of capped primers as well as the cap-binding and endonuclease activities of the viral polymerase needed for cap snatching have been functionally and structurally well characterized, our knowledge on the expected counterparts of cytoplasmic replicating bunyaviruses is still limited and controversial. This review focuses on the cap-snatching mechanism of bunyaviruses in the light of recent structural and functional data.
与所有分段负义 RNA 病毒一样，布尼亚病毒的转录本在其 5' 末端包含来自带帽宿主细胞 RNA 的异源序列。这些异源序列是通过所谓的帽抢夺机制获得的。虽然对于核复制的流感病毒，已经对用于帽抢夺的带帽引物的来源以及病毒聚合酶的帽结合和内切酶活性进行了功能和结构上的很好的描述，但是我们对细胞质复制布尼亚病毒的预期对应物的了解仍然有限且存在争议。本文综述了根据最近的结构和功能数据对布尼亚病毒的帽抢夺机制的研究。
