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The microbial-derived bile acid lithocholate and its epimers inhibit growth and pathogenicity while sparing members of the gut microbiota.微生物衍生的胆汁酸石胆酸及其差向异构体抑制 生长和致病性，同时不影响肠道微生物群的成员。
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Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection.艰难梭菌感染粪便微生物群移植成功后微生物群组成、胆汁和脂肪酸代谢的变化
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Impact of Primary and Secondary Bile Acids on Infection.初级和次级胆汁酸对感染的影响。
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Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu Powder regulating gut microbiota and bile acids.总苷通过调节肠道菌群和胆汁酸发挥其止泻作用。
Front Cell Infect Microbiol. 2022 Aug 22;12:945263. doi: 10.3389/fcimb.2022.945263. eCollection 2022.
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Therapeutic Effects of Bifidobacterium breve YH68 in Combination with Vancomycin and Metronidazole in a Primary Clostridioides difficile-Infected Mouse Model.短双歧杆菌 YH68 联合万古霉素和甲硝唑对原发性艰难梭菌感染小鼠模型的治疗效果。
Microbiol Spectr. 2022 Apr 27;10(2):e0067222. doi: 10.1128/spectrum.00672-22. Epub 2022 Mar 21.
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Bile acid-independent protection against Clostridioides difficile infection.胆汁酸非依赖性预防艰难梭菌感染。
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10
Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection.溃疡性结肠炎合并艰难梭菌感染患儿次级粪便胆汁酸减少。
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本文引用的文献

1
Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection.人际肠道微生物组的变化会导致霍乱感染的易感性和抗性。
Cell. 2020 Jun 25;181(7):1533-1546.e13. doi: 10.1016/j.cell.2020.05.036. Epub 2020 Jun 16.
2
Gut microbiome communication with bone marrow regulates susceptibility to amebiasis.肠道微生物组与骨髓的交流调节阿米巴病易感性。
J Clin Invest. 2020 Aug 3;130(8):4019-4024. doi: 10.1172/JCI133605.
3
Strain-Dependent Inhibition of Clostridioides difficile by Commensal Carrying the Bile Acid-Inducible () Operon.依赖于应变的共生菌携带胆汁酸诱导（）操纵子对艰难梭菌的抑制作用。
J Bacteriol. 2020 May 11;202(11). doi: 10.1128/JB.00039-20.
4
Bile acid metabolites control T17 and T cell differentiation.胆汁酸代谢物控制 T17 和 T 细胞分化。
Nature. 2019 Dec;576(7785):143-148. doi: 10.1038/s41586-019-1785-z. Epub 2019 Nov 27.
5
Diversification of host bile acids by members of the gut microbiota.肠道微生物群成员对宿主胆汁酸的多样化作用。
Gut Microbes. 2020;11(2):158-171. doi: 10.1080/19490976.2019.1674124. Epub 2019 Oct 9.
6
Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract.胆汁盐水解酶：胃肠道中胆汁酸代谢和宿主-微生物群相互作用的守门人。
PLoS Pathog. 2019 Mar 7;15(3):e1007581. doi: 10.1371/journal.ppat.1007581. eCollection 2019 Mar.
7
Restoration of short chain fatty acid and bile acid metabolism following fecal microbiota transplantation in patients with recurrent Clostridium difficile infection.复发性艰难梭菌感染患者粪便微生物群移植后短链脂肪酸和胆汁酸代谢的恢复
Anaerobe. 2018 Oct;53:64-73. doi: 10.1016/j.anaerobe.2018.04.001. Epub 2018 Apr 12.
8
The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis.胆汁酸受体GPBAR1调节肠道巨噬细胞的M1/M2表型，激活GPBAR1可使小鼠免受小鼠结肠炎的影响。
J Immunol. 2017 Jul 15;199(2):718-733. doi: 10.4049/jimmunol.1700183. Epub 2017 Jun 12.
9
Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles.复发性艰难梭菌感染与独特的胆汁酸和微生物群谱相关。
Aliment Pharmacol Ther. 2016 Jun;43(11):1142-53. doi: 10.1111/apt.13616. Epub 2016 Apr 18.
10
Updated global burden of cholera in endemic countries.流行国家霍乱的全球负担最新情况。
PLoS Negl Trop Dis. 2015 Jun 4;9(6):e0003832. doi: 10.1371/journal.pntd.0003832. eCollection 2015.

肠道感染中微生物衍生胆汁酸的作用。

Role of Microbiota-Derived Bile Acids in Enteric Infections.

机构信息

North Carolina State University, Raleigh, NC, USA.

Department of Medicine, University of Virginia, PO Box 801340, Charlottesville, VA 22908-1340, USA.

出版信息

Cell. 2020 Jun 25;181(7):1452-1454. doi: 10.1016/j.cell.2020.05.033.

DOI:10.1016/j.cell.2020.05.033
PMID:32589955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8162987/
Abstract

In this issue of Cell, Alavi et al. report that infection by Vibrio cholerae is blocked by gut microbiome-mediated hydrolysis of bile acids. Cholera therefore joins amebic dysentery and Clostridioides difficile colitis as enteric infections profoundly influenced by the microbiome's impact on bile acid metabolism.

摘要

本期《细胞》杂志上，Alavi 等人报告称，肠道微生物组介导的胆汁酸水解可阻止霍乱弧菌感染。因此，霍乱与阿米巴痢疾和艰难梭菌结肠炎一道，成为受微生物组影响胆汁酸代谢而显著改变的肠道感染。