肠道感染中微生物衍生胆汁酸的作用。
Role of Microbiota-Derived Bile Acids in Enteric Infections.
机构信息
North Carolina State University, Raleigh, NC, USA.
Department of Medicine, University of Virginia, PO Box 801340, Charlottesville, VA 22908-1340, USA.
出版信息
Cell. 2020 Jun 25;181(7):1452-1454. doi: 10.1016/j.cell.2020.05.033.
Abstract
In this issue of Cell, Alavi et al. report that infection by Vibrio cholerae is blocked by gut microbiome-mediated hydrolysis of bile acids. Cholera therefore joins amebic dysentery and Clostridioides difficile colitis as enteric infections profoundly influenced by the microbiome's impact on bile acid metabolism.
摘要
本期《细胞》杂志上，Alavi 等人报告称，肠道微生物组介导的胆汁酸水解可阻止霍乱弧菌感染。因此，霍乱与阿米巴痢疾和艰难梭菌结肠炎一道，成为受微生物组影响胆汁酸代谢而显著改变的肠道感染。
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J Immunol. 2017 Jul 15;199(2):718-733. doi: 10.4049/jimmunol.1700183. Epub 2017 Jun 12.
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