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Cyclosporine does not inhibit the early transducing signals generated by the activation of human thymocytes.

作者信息

Schleuning M, Duggan A, Reem G H

机构信息

Department of Pharmacology, New York University Medical Center, NY 10016.

出版信息

Transplant Proc. 1988 Apr;20(2 Suppl 2):63-8.

PMID:3259043
Abstract
摘要

相似文献

1
Cyclosporine does not inhibit the early transducing signals generated by the activation of human thymocytes.环孢素并不抑制人类胸腺细胞激活所产生的早期转导信号。
Transplant Proc. 1988 Apr;20(2 Suppl 2):63-8.
2
Immunoregulation and production of tumor necrosis factor alpha by human thymocytes.人胸腺细胞的免疫调节及肿瘤坏死因子α的产生
Cancer Res. 1989 Jul 1;49(13):3568-73.
3
Effect of cyclosporine A on early stages of T cell activation.环孢素A对T细胞活化早期阶段的影响。
Transplant Proc. 1987 Feb;19(1 Pt 2):1186-8.
4
Inhibition by chlorpromazine of lymphokine-specific mRNA expression in human thymocytes.氯丙嗪对人胸腺细胞中淋巴因子特异性mRNA表达的抑制作用。
Eur J Immunol. 1989 Aug;19(8):1491-5. doi: 10.1002/eji.1830190822.
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Cyclosporine does not inhibit mitogen-induced inositol phospholipid degradation in mouse lymphocytes.环孢素不抑制丝裂原诱导的小鼠淋巴细胞中肌醇磷脂的降解。
Immunology. 1985 Nov;56(3):435-40.
6
Lymphocyte activation by OKT3: cyclosporine sensitivity and synergism with phorbol ester.OKT3 介导的淋巴细胞激活:环孢素敏感性及与佛波酯的协同作用
Immunology. 1986 Feb;57(2):195-9.
7
Stimulation of phosphatidylinositol turnover by concanavalin A is not sufficient to activate mouse thymocytes.
Biochem Biophys Res Commun. 1986 Dec 15;141(2):657-64. doi: 10.1016/s0006-291x(86)80223-6.
8
Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes.T细胞活化涉及的分子机制。II. 磷脂酰肌醇信号转导机制介导抗原诱导的淋巴因子产生,但不介导克隆化细胞毒性T淋巴细胞中白细胞介素2诱导的增殖。
J Immunol. 1987 Jan 15;138(2):606-12.
9
Cyclosporin A inhibits late steps of T lymphocyte activation after transmembrane signaling.环孢菌素A在跨膜信号传导后抑制T淋巴细胞活化的后期步骤。
J Biochem. 1987 Nov;102(5):1193-201. doi: 10.1093/oxfordjournals.jbchem.a122158.
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Endothelin-stimulated phosphoinositide turnover and protein kinase C translocation in rat synaptosomes.
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引用本文的文献

1
Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives.吩噻嗪衍生物对环孢菌素A/ FK506耐药的、淋巴因子诱导的T细胞活化的抑制作用
Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):100-3. doi: 10.1007/BF00180018.
2
Tumor necrosis factor: an update on basic research and clinical applications.肿瘤坏死因子:基础研究与临床应用的最新进展
Klin Wochenschr. 1990 Sep 3;68(17):841-6. doi: 10.1007/BF01662779.
3
Comparison of the properties of the CsA analogs monoacetyl CyC (o-acetyl-threonine2 cyclosporin) and methyl-alanyl CsA (N-methyl-L-alanyl6 cyclosporin); monoacetyl cyclosporin is immunosuppressive without binding to cyclophilin.
环孢素A类似物单乙酰环孢素(邻乙酰基-苏氨酸2-环孢素)和甲基丙氨酰环孢素A(N-甲基-L-丙氨酰6-环孢素)的性质比较;单乙酰环孢素具有免疫抑制作用但不与亲环蛋白结合。
Clin Exp Immunol. 1992 Jul;89(1):136-42. doi: 10.1111/j.1365-2249.1992.tb06892.x.