Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia.
Pancreas. 2020 Jul;49(6):845-854. doi: 10.1097/MPA.0000000000001587.
Existing reference ranges for stool fat and energy absorption were developed using subjects in controlled environments on precise diets. This study measured energy and fat absorption in healthy, community-dwelling adults eating a moderate-to-high fat American diet via stool- and serum-based methods.
This was a secondary analysis of healthy subjects recruited as the comparison group in a chronic pancreatitis study. Subjects recorded dietary intake and collected stool over 3-day periods. Stool was analyzed for fat content using the coefficient of fat absorption and for energy content using bomb calorimetry. The malabsorption blood test (MBT) was used to measure dietary fat absorption.
Nineteen subjects had mean daily stool measures of 143 g wet weight, 4.1 g of fat, and 178 kcal. The mean coefficients of fat and energy absorption were 96% and 93%, respectively. The mean MBT area under the curve cut-point was greater than 8 mg·h/dL.
This study confirms the historical reference range for the coefficient of fat absorption in contemporary healthy, community-dwelling adults on a moderate-to-high fat diet. The study contributes to the development of reference range values for multiple bomb calorimetry-based outcomes of stool energy losses and to the serum-based MBT as a promising method for measuring fat absorption.
现有的粪便脂肪和能量吸收参考范围是通过在受控环境中使用精确饮食的受试者制定的。本研究通过粪便和血清方法测量了食用中高脂肪美国饮食的健康社区居民的能量和脂肪吸收情况。
这是一项慢性胰腺炎研究中作为对照组招募的健康受试者的二次分析。受试者记录了饮食摄入量，并在 3 天内收集了粪便。使用脂肪吸收系数分析粪便中的脂肪含量，使用弹式热量计分析能量含量。使用脂肪吸收不良血液测试 (MBT) 来测量膳食脂肪吸收情况。
19 名受试者的平均每日粪便湿重为 143 克，脂肪 4.1 克，热量 178 卡路里。脂肪和能量吸收的平均系数分别为 96%和 93%。平均 MBT 曲线下面积切点大于 8mg·h/dL。
本研究证实了当代健康社区居民在中高脂肪饮食下脂肪吸收系数的历史参考范围。该研究为基于多种弹式热量计的粪便能量损失的参考范围值的制定以及 MBT 作为测量脂肪吸收的有前途的方法做出了贡献。
