丙泊酚持续输注在肝硬化患者中的药代动力学。初步结果。

Pharmacokinetics of propofol administered by continuous infusion in patients with cirrhosis. Preliminary results.

作者信息

Servin F, Desmonts J M, Farinotti R, Haberer J P, Winckler C

机构信息

University Hospital Centre, Paris, France.

出版信息

Anaesthesia. 1988 Mar;43 Suppl:23-4. doi: 10.1111/j.1365-2044.1988.tb09063.x.

DOI:10.1111/j.1365-2044.1988.tb09063.x

PMID:3259091

Abstract

Anaesthesia was provided by an infusion of propofol in six healthy patients and six patients with hepatic cirrhosis. There were no significant differences between the groups with regard to the central compartment volume, distribution volume at steady state, total apparent distribution volume, total body clearance or elimination half-life, although the values were always greater in the cirrhotic patients. Recovery times were significantly longer in the patients with cirrhosis.

摘要

对6名健康患者和6名肝硬化患者通过输注丙泊酚实施麻醉。两组在中央室容积、稳态分布容积、总表观分布容积、全身清除率或消除半衰期方面无显著差异，尽管肝硬化患者的这些数值始终更高。肝硬化患者的恢复时间明显更长。