丙泊酚对人体脑血流及代谢的影响。
Effect of propofol on cerebral blood flow and metabolism in man.
作者信息
Vandesteene A, Trempont V, Engelman E, Deloof T, Focroul M, Schoutens A, de Rood M
机构信息
Department of Isotopes, Erasme Hospital, Free University of Brussels, Belgium.
出版信息
Anaesthesia. 1988 Mar;43 Suppl:42-3. doi: 10.1111/j.1365-2044.1988.tb09067.x.
Cerebral blood flow, cerebral oxygen consumption, lactate and glucose metabolism were measured in 13 patients during anaesthesia with nitrous oxide, oxygen and enflurane 0.5% and after 30 minutes infusion of propofol. The mean blood concentration of propofol was 4.06 micrograms/ml. Cerebral blood flow decreased by 27.6% and cerebral vascular resistance by 51%. There were no changes in lactate and glucose metabolism. Cerebral oxygen consumption decreased by 18.25%. Changes in the electro-encephalograph were related to the blood levels of propofol.
对13例患者在使用氧化亚氮、氧气和0.5%安氟醚麻醉期间以及输注丙泊酚30分钟后，测量其脑血流量、脑氧耗量、乳酸和葡萄糖代谢情况。丙泊酚的平均血药浓度为4.06微克/毫升。脑血流量下降了27.6%，脑血管阻力下降了51%。乳酸和葡萄糖代谢无变化。脑氧耗量下降了18.25%。脑电图的变化与丙泊酚的血药浓度有关。
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