Maurette P, Simeon F, Castagnera L, Esposito J, Macouillard G, Heraut L A
Department of Anaesthesia, Pellegrin Hospital, Bordeaux, France.
Anaesthesia. 1988 Mar;43 Suppl:44-5. doi: 10.1111/j.1365-2044.1988.tb09068.x.
This study evaluated the effects of propofol on somatosensory evoked cortical potentials in 20 ASA grade 1 or 2 patients who underwent spinal surgery. Anaesthesia consisted of propofol, dextromoramide, 50% nitrous oxide and oxygen mixture. The induction dose of propofol was 2 mg/kg and was followed by an infusion of 6 mg/kg for the first hour and 3 mg/kg subsequently. Somatosensory evoked cortical potentials were recorded on the scalp and compared to pre-operative values using Student's paired t-test. We observed a significant depression of evoked potential 10 minutes after induction, which continued until the early phase of recovery. Because of its short and quickly reversible action, propofol is an acceptable agent when clinical monitoring of the spinal cord is indicated but is not satisfactory when monitoring has to be based on somatosensory cortical evoked potentials.
本研究评估了丙泊酚对20例接受脊柱手术的美国麻醉医师协会（ASA）1或2级患者体感诱发电位的影响。麻醉由丙泊酚、右吗拉胺、50%氧化亚氮和氧气混合气体组成。丙泊酚的诱导剂量为2mg/kg，随后第1小时输注6mg/kg，之后输注3mg/kg。在头皮上记录体感诱发电位，并使用学生配对t检验与术前值进行比较。我们观察到诱导后10分钟诱发电位显著降低，这种降低持续到恢复早期。由于其作用时间短且快速可逆，当需要对脊髓进行临床监测时，丙泊酚是一种可接受的药物，但当监测必须基于体感皮层诱发电位时，它并不令人满意。
