Dubois A, Balatoni E, Peeters J P, Baudoux M
Department of Anaesthesiology, University Hospital Centre André Vésale, Montignies-le-Tilleul, Belgium.
Anaesthesia. 1988 Mar;43 Suppl:75-80. doi: 10.1111/j.1365-2044.1988.tb09078.x.
This study investigated the suitability of propofol as a sole agent for continuous sedation in 100 unpremedicated patients during gastrointestinal endoscopy. The propofol was given very slowly (average 62.7 seconds) in order to prevent apnoea during induction, and the dose adjusted according to age (68% of patients were older than 50 years) and ASA grade (32% were ASA grade 3 or 4). There was no correlation under these circumstances between the observed haemodynamic variations and the age or ASA grade of the patients. The infusion rate during maintenance was also adjusted for age, and for the type of endoscopy. The mean rate was 4.3 mg/kg/hour. Recovery was rapid and of excellent quality; 77 patients were awake within 10 minutes and 99 reported total amnesia.
本研究调查了丙泊酚作为100例未进行术前用药的患者在胃肠内镜检查期间持续镇静的单一用药的适用性。丙泊酚给药速度非常缓慢（平均62.7秒），以防止诱导期呼吸暂停，并根据年龄（68%的患者年龄超过50岁）和美国麻醉医师协会（ASA）分级（32%为ASA 3级或4级）调整剂量。在这些情况下，观察到的血流动力学变化与患者年龄或ASA分级之间无相关性。维持期的输注速率也根据年龄和内镜检查类型进行调整。平均速率为4.3毫克/千克/小时。苏醒迅速且质量良好；77例患者在10分钟内清醒，99例报告完全遗忘。
