Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, United States.
Curr Top Dev Biol. 2020;140:317-340. doi: 10.1016/bs.ctdb.2019.10.006. Epub 2019 Nov 19.
Mammalian embryogenesis depends on maternal factors accumulated in eggs prior to fertilization and on placental transfers later in gestation. In this review, we focus on initial events when the organism has insufficient newly synthesized embryonic factors to sustain development. These maternal factors regulate preimplantation embryogenesis both uniquely in pronuclear formation, genome reprogramming and cell fate determination and more universally in regulating cell division, transcription and RNA metabolism. Depletion, disruption or inappropriate persistence of maternal factors can result in developmental defects in early embryos. To better understand the origins of these maternal effects, we include oocyte maturation processes that are responsible for their production. We focus on recent publications and reference comprehensive reviews that include earlier scientific literature of early mouse development.
哺乳动物胚胎发生依赖于受精前卵子中积累的母体因子和妊娠后期胎盘的转运。在这篇综述中，我们重点关注当生物体没有足够新合成的胚胎因子来维持发育时的初始事件。这些母体因子在原核形成、基因组重编程和细胞命运决定方面独特地调节着胚胎的着床前发育，在调节细胞分裂、转录和 RNA 代谢方面也具有普遍性。母体因子的耗尽、破坏或不适当的持续存在可能导致早期胚胎发育缺陷。为了更好地理解这些母体效应的起源，我们包括了负责其产生的卵母细胞成熟过程。我们重点关注最近的出版物，并参考了包括早期小鼠发育在内的更广泛的科学文献的综合评论。
