Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Am J Med Sci. 2020 Sep;360(3):222-228. doi: 10.1016/j.amjms.2020.05.036. Epub 2020 May 28.
The present review aimed to present the research highlights on C1q/TNF-related protein 1 (CTRP1), a member of the recently discovered family of highly conserved adiponectin paralog proteins, C1q tumor necrosis factor-related proteins. CTRP1 plays an important role in regulating body energy homeostasis and sensitivity to insulin. Studies on animal models have shown that it lowers the concentration of glucose. Elevated concentrations of CTRP1 reduce weight gain and diet-induced insulin resistance. CTRP1 limits the extent of ischemia-reperfusion injury in acute myocardial infarction. It inhibits platelet aggregation by blocking von Willebrand factor binding to collagen. In patients with chronic kidney disease, an increase in CTRP1 levels is associated with a lesser degree of disease progression. CTRP1 stimulates aldosterone synthesis in the adrenal cortex by affecting aldosterone synthase expression. In dehydration, an increase in CTRP1 concentration helps to maintain normotension. It participates in processes related to the proliferation and maturation of chondrocytes. It also promotes atherosclerosis, and a surge in its concentration is correlated with a higher cardiovascular risk in patients with coronary atherosclerosis. In vascular smooth muscle cells, it induces the expression of proinflammatory cytokines. An increase in CTRP1 levels is correlated with the progression of the neoplastic process in patients with glioblastoma.
本综述旨在介绍 C1q/肿瘤坏死因子相关蛋白 1（CTRP1）的研究亮点，CTRP1 是新近发现的高度保守脂联素类蛋白家族的成员之一，即 C1q 肿瘤坏死因子相关蛋白。CTRP1 在调节机体能量平衡和胰岛素敏感性方面发挥着重要作用。动物模型研究表明，它可降低血糖浓度。CTRP1 浓度升高可减轻体重增加和饮食诱导的胰岛素抵抗。CTRP1 可限制急性心肌梗死时的缺血再灌注损伤程度。它通过阻断血管性血友病因子与胶原的结合来抑制血小板聚集。在慢性肾脏病患者中，CTRP1 水平的升高与疾病进展程度较轻相关。CTRP1 通过影响醛固酮合酶的表达来刺激肾上腺皮质合成醛固酮。在脱水时，CTRP1 浓度的增加有助于维持正常血压。它参与软骨细胞增殖和成熟的相关过程。它还可促进动脉粥样硬化形成，其浓度的激增与冠状动脉粥样硬化患者的心血管风险升高相关。在血管平滑肌细胞中，它可诱导促炎细胞因子的表达。CTRP1 水平的升高与胶质母细胞瘤患者肿瘤进展过程相关。
