Salazar M, Barochiner J, Espeche W, Ennis I
Sociedad Argentina de Hipertensión Arterial, Ciudad Autónoma de Buenos Aires, Argentina; Hospital Interzonal General de Agudos «General José de San Martín», La Plata, Buenos Aires, Argentina.
Sociedad Argentina de Hipertensión Arterial, Ciudad Autónoma de Buenos Aires, Argentina; Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
Hipertens Riesgo Vasc. 2020 Oct-Dec;37(4):176-180. doi: 10.1016/j.hipert.2020.06.003. Epub 2020 Jun 18.
The association between hypertension, diabetes, cardio and cerebrovascular disease and severe and fatal COVID-19, described in different countries, is remarkable. Myocardial damage and myocardial dysfunction are postulated as a possible causal nexus. Frequent findings of elevated troponin levels and electrocardiographic anomalies support this concept. On the other hand, hypotheses in favour and against a deleterious effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers, a usual treatment for cardiovascular disease, have been raised. There is currently no solid evidence and thus properly designed studies on this subject are urgently needed. In this context, patients with cardiovascular disease should especially avoid being exposed to the virus, should not self-medicate and rapidly seek medical advice should they show symptoms of infection.
不同国家所描述的高血压、糖尿病、心脑血管疾病与重症及致死性新冠肺炎之间的关联十分显著。心肌损伤和心肌功能障碍被假定为一种可能的因果联系。肌钙蛋白水平升高和心电图异常的常见表现支持了这一概念。另一方面,对于心血管疾病常用治疗药物血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂的有害作用,出现了支持和反对的两种假说。目前尚无确凿证据,因此迫切需要针对该主题进行设计合理的研究。在此背景下,心血管疾病患者应特别避免接触病毒,不应自行用药,一旦出现感染症状应迅速寻求医疗建议。