淋巴因子激活的杀伤细胞可裂解人肾癌细胞系及培养的正常肾细胞。
Lymphokine-activated killer cells lyse human renal cancer cell lines and cultured normal kidney cells.
作者信息
Miltenburg A M, Meijer-Paape M E, Daha M R, Paul L C
机构信息
Department of Nephrology, University Hospital Leiden, The Netherlands.
出版信息
Immunology. 1988 Apr;63(4):729-31.
In this study, we investigated whether or not lymphokine-activated killer (LAK) cells can damage renal tissue and therefore whether they may contribute to graft destruction during kidney allograft rejection. Human peripheral blood mononuclear cells were activated with a lymphokine preparation and the resulting LAK cells were tested against kidney cells from various sources. Renal cancer cells as well as cultured normal kidney cells were efficiently lysed by LAK cells, as assessed with Cr-labelled target cells, showing that both cell types are sensitive to LAK cell-mediated cytolysis.
在本研究中，我们调查了淋巴因子激活的杀伤（LAK）细胞是否会损害肾组织，以及它们是否可能在肾移植排斥反应期间导致移植物破坏。用人外周血单个核细胞与一种淋巴因子制剂一起激活，然后将产生的LAK细胞用于检测来自各种来源的肾细胞。用铬标记的靶细胞评估发现，肾癌细胞以及培养的正常肾细胞均被LAK细胞有效裂解，表明这两种细胞类型均对LAK细胞介导的细胞溶解敏感。
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