Sayed Khadiga S, Tuqan Samar, Hilal Rana F
Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Lasers Surg Med. 2021 Mar;53(3):324-332. doi: 10.1002/lsm.23291. Epub 2020 Jun 26.
To compare the efficacy and safety of intradermal injection of tranexamic acid (TXA) versus Q switched (QS) KTP (532 nm) in the treatment of facial ephelides.
STUDY DESIGN/MATERIALS AND METHODS: A randomized comparative split-face study included a total of 30 female patients with bilateral facial ephelides. One cheek was treated by intra-dermal TXA injections and the other was treated by QS-KTP (532 nm). Patient assessment was performed by photography, pigmentation area, severity index and spectrophotometry at baseline, 1 week after treatment, and 2 months after treatment.
A significant difference was found between both sides regarding the percentage change of pigmentation area, severity score (PSI) and melanin index (MI) after treatment and during follow up, favoring laser (P = 0.001). PSI decreased after treatment by 66.5% and 15.4% (laser and TXA sides respectively), further decrease after follow-up was 69.4% with laser and 26.1% with TXA. MI improved by 3.7% after KTP laser to 7.7% after follow-up and by 2.4% after TXA injections to 6.5% after follow-up. Four patients developed post-inflammatory hyperpigmentation following QS-KTP.
QS-KTP laser is superior to intradermal TXA injection in the treatment of facial ephelides. Lasers Surg. Med. © 2020 Wiley Periodicals LLC.
比较皮内注射氨甲环酸（TXA）与调Q开关（QS）倍频Nd:YAG（532 nm）激光治疗面部雀斑的疗效和安全性。
研究设计/材料与方法：一项随机对照半脸研究，共纳入30例双侧面部有雀斑的女性患者。一侧脸颊采用皮内注射TXA治疗，另一侧采用QS-KTP（532 nm）激光治疗。在基线、治疗后1周和治疗后2个月，通过拍照、色素沉着面积、严重程度指数和分光光度法对患者进行评估。
治疗后及随访期间，两侧在色素沉着面积变化百分比、严重程度评分（PSI）和黑色素指数（MI）方面存在显著差异，激光治疗组更具优势（P = 0.001）。治疗后PSI分别下降66.5%（激光治疗侧）和15.4%（TXA注射侧），随访后激光治疗组进一步下降69.4%，TXA注射组下降26.1%。KTP激光治疗后MI改善3.7%，随访后改善至7.7%；TXA注射后MI改善2.4%，随访后改善至6.5%。4例患者在QS-KTP激光治疗后出现炎症后色素沉着。
在治疗面部雀斑方面，QS-KTP激光优于皮内注射TXA。激光外科医学。© 2020威利期刊有限责任公司。
