Rodenhiser D I, Atkinson B G, Jung J H
Department of Zoology, University of Western Ontario, London, Canada.
J Cell Physiol. 1988 Apr;135(1):145-50. doi: 10.1002/jcp.1041350121.
Short-term hyperthermic episodes (in vivo and in vitro) alter gene expression in mammalian lymphocytes, resulting in the enhanced synthesis of a select group of polypeptides--the heat-shock proteins--and the depressed synthesis of many normally synthesized polypeptides. Such alterations could have profound implications to an individual if the appropriate functioning of lymphocytes within the immune response was compromised by a depression in immunoglobulin synthesis during naturally occurring periods of hyperthermia, such as fever. In the present study we asked if heat-shock affects the facultative synthesis and secretion of immunoglobulin G by cultured mouse lymphocytes. We found that the quantity of immunoglobulin G synthesized and secreted by these cells is not affected by heat-shock treatments sufficient to induce the synthesis of heat-shock proteins.
短期热暴露（体内和体外）会改变哺乳动物淋巴细胞中的基因表达，导致一组特定多肽——热休克蛋白——的合成增强，以及许多正常合成的多肽的合成受到抑制。如果在自然发生的热暴露期（如发烧）期间，免疫球蛋白合成的减少损害了淋巴细胞在免疫反应中的正常功能，那么这种改变可能会对个体产生深远影响。在本研究中，我们探究热休克是否会影响培养的小鼠淋巴细胞中免疫球蛋白G的适应性合成和分泌。我们发现，这些细胞合成和分泌的免疫球蛋白G的量不受足以诱导热休克蛋白合成的热休克处理的影响。
