Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, Tamilnadu, India.
Central Research laboratory, Vinayaka Mission Research Foundation (Deemed to be University), Vinayaka Missions Medical College and Hospital, Karaikal, Puducherry, India.
Microb Pathog. 2020 Oct;147:104352. doi: 10.1016/j.micpath.2020.104352. Epub 2020 Jun 24.
Salmonellosis continues to remain a health problem as the causative organism Salmonella spp. developed resistance to many of the antibiotics. As per World Health Organization (WHO), it is estimated that enteric fever, accounts for almost 16 million cases annually and over 600,000 deaths worldwide. Recent data revealed that the multi-drug resistance (MDR) rate of enteric fever was as high as 70% in Asian countries, as compared with the overall reported incidence of 50%. Emergence of MDR typhoid fever demands the use of newer antibiotics which also not offer promising effect in recent days. Effective antimicrobial therapy is required to control morbidity and prevent death from typhoid fever. The studies on PhoP/Q regulation revealed it as a best-characterized transcriptional regulation; a two-component system required for Salmonella pathogenesis which controls the expression of more than 40 genes. The PhoP DNA binding proteins possess positively charged amino acids such as arginine, lysine and histidine which present in the DNA binding site. Prevention of PhoP binding in phoP box may ultimately prevent the expression of many regulatory mechanism which plays vital role in Salmonella virulence. Deepness study of PhoP protein and various mutation swots may offer effectual controlling of MDR Salmonella.
沙门氏菌病仍然是一个健康问题，因为病原体沙门氏菌对许多抗生素产生了耐药性。根据世界卫生组织（WHO）的估计，每年全世界有近 1600 万例肠热病病例，超过 60 万人死亡。最近的数据显示，亚洲国家肠热病的多重耐药（MDR）率高达 70%，而全球报告的发病率为 50%。MDR 伤寒的出现需要使用新的抗生素，但这些抗生素在最近几天也没有带来有希望的效果。有效的抗菌治疗是控制发病率和预防伤寒死亡的必要条件。PhoP/Q 调节的研究揭示了它是一个最佳特征化的转录调节；沙门氏菌发病机制所需的双组分系统控制着 40 多个基因的表达。PhoP DNA 结合蛋白具有带正电荷的氨基酸，如精氨酸、赖氨酸和组氨酸，这些氨基酸存在于 DNA 结合位点中。防止 PhoP 在 phoP 盒中的结合可能最终阻止许多调节机制的表达，这些调节机制在沙门氏菌的毒力中起着至关重要的作用。对 PhoP 蛋白和各种突变热点的深入研究可能为控制 MDR 沙门氏菌提供有效的方法。
