二甲双胍在 COVID-19 中可能具有治疗潜力的一种拟议机制。
A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19.
机构信息
Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
出版信息
Diabetes Res Clin Pract. 2020 Sep;167:108282. doi: 10.1016/j.diabres.2020.108282. Epub 2020 Jun 25.
Abstract
The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19.
摘要
目前，全世界都在艰难应对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)。对于这种病毒感染，还没有特效药物。因此，我们正在尝试用非特异性药物鸡尾酒治疗患者。二甲双胍作为一种强碱，是液泡型三磷酸腺苷酶 (V-ATPase) 和内体 Na+/H+交换器 (eNHEs) 的潜在调节剂，同时也是肺纤维化的再生剂，似乎对 COVID-19 的急性、慢性和恢复期患者都有益。
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