Karatabanova N A, Arkhapchev Iu P, Sergeev I N, Linberg L F, Spirichev V B
Vopr Med Khim. 1988 Jan-Feb;34(1):83-6.
Short-term administration of hydrocortisone into rats (within 7 days) stimulated 1.25(OH)2D3 synthesis in kidney and led to accumulation of the metabolite in blood serum, small intestinal mucose and bones. After long-term administration of hydrocortisone within 28 days synthesis of 1.25(OH2D3) was decreased in kidney while the content of 24.25(OH)2D3 was was simultaneously increased. Concentration of labelled 1.25 (OH)2D3 and 24.25(OH)2D3 was distinctly decreased in small intestinal mucose and femur bones.
给大鼠短期（7天内）注射氢化可的松会刺激肾脏中1,25(OH)₂D₃的合成，并导致该代谢产物在血清、小肠黏膜和骨骼中蓄积。在28天内长期注射氢化可的松后，肾脏中1,25(OH)₂D₃的合成减少，而24,25(OH)₂D₃的含量同时增加。小肠黏膜和股骨中标记的1,25(OH)₂D₃和24,25(OH)₂D₃浓度明显降低。
