高脂血症和高血压对2型糖尿病与痛风之间关联的效应修正
Effect modification of hyperlipidemia and hypertension on the association between type 2 diabetes and gout.
作者信息
Tung Yi-Ching, Lee Mei-Yueh, Wang Yi-Chi, Chang Chai-Jan, Tsai Wen-Chan, Lin Gau-Tyan, Li Chia-Yang, Lee Su-Shin, Tu Hung-Pin
机构信息
Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Prim Care Diabetes. 2020 Dec;14(6):654-662. doi: 10.1016/j.pcd.2020.06.002. Epub 2020 Jun 24.
AIMS
We evaluated the association between type 2 diabetes and gout by a retrospective cohort study.
METHODS
Data of 17,259 male and 18,318 female patients with type 2 diabetes were retrieved for the 1998-2010 period. These patients were matched to a comparison group (n=34,518 and n=36,636, respectively) in a 1:2 ratio by age and region.
RESULTS
We found that patients with type 2 diabetes after adjustment for hyperlipidemia and hypertension had a lower risk of incident gout than the matched population (incidence rate ratio, men: 0.39 [95% CI: 0.36-0.42]; women: 0.78 [0.72-0.84]). Specifically, type 2 diabetes alone without hyperlipidemia and hypertension was associated with a reduced risk of incident gout in men (adjusted relative risk [RR]: 0.29, 95% CI: 0.22-0.39), but not in women (0.86, 95% CI: 0.55-1.36). We found that insulin users with hyperlipidemia and hypertension associated with risk of incident gout and no sex-specific differences were noted (adjusted RR, men: 1.28 [95% CI: 1.11-1.48]; women: 1.32 [95% CI: 1.14-1.53]). Specifically, insulin users alone without hyperlipidemia and hypertension were not statistically significantly associated with gout risk (P≥.0954).
CONCLUSIONS
The results of this study indicated that hyperlipidemia and hypertension modified the association between type 2 diabetes and gout.
目的
我们通过一项回顾性队列研究评估2型糖尿病与痛风之间的关联。
方法
检索了1998 - 2010年期间17259例男性和18318例女性2型糖尿病患者的数据。这些患者按年龄和地区以1:2的比例与一个对照组（分别为n = 34518和n = 36636）进行匹配。
结果
我们发现，在调整高脂血症和高血压因素后，2型糖尿病患者发生痛风的风险低于匹配人群（发病率比，男性：0.39 [95%可信区间：0.36 - 0.42]；女性：0.78 [0.72 - 0.84]）。具体而言，单纯2型糖尿病且无高脂血症和高血压与男性发生痛风的风险降低相关（调整后相对风险[RR]：0.29，95%可信区间：0.22 - 0.39），但与女性无关（0.86，95%可信区间：0.55 - 1.36）。我们发现，伴有高脂血症和高血压的胰岛素使用者发生痛风的风险增加，且无性别差异（调整后RR，男性：1.28 [95%可信区间：1.11 - 1.48]；女性：1.32 [95%可信区间：1.14 - 1.53]）。具体而言，单纯胰岛素使用者且无高脂血症和高血压与痛风风险无统计学显著关联（P≥0.0954）。
结论
本研究结果表明，高脂血症和高血压改变了2型糖尿病与痛风之间的关联。
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