Rabea Ali R, Elshahid Ahmed R, Elhakim Mohamed S, Hashish Yahia H, Jafferany Mohammad, Elsaie Mohamed L
Department of Dermatology, Al Azhar University, Cairo, Egypt.
Department of Pathology, Al Azhar University, Cairo, Egypt.
Dermatol Ther. 2020 Nov;33(6):e13921. doi: 10.1111/dth.13921. Epub 2020 Aug 5.
Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of the stem cell marker nestin, in Squaous cell carcinoma (SCC) and basal cell carcinoma (BCC). The samples (23 cases of BCC and 22 cases of SCC) were immunohistochemically examined for the expression of nestin and its correlation with the corresponding clinical and pathological parameters. Nestin was expressed in four out of the 23 cases of BCC (17.4%) and was expressed in 10 out of the 22 cases of SCC (45.5%). Nestin expression between the two tumors was statistically significant (P = .042). Although a direct relationship was found between the tumor grade and nestin expression, the results were statistically insignificant (P = .495). The results of this study suggest that BCC and SCC may share some cellular origin but with different biologic behavior. The relation of nestin expression to the grade of SCC, although statistically insignificant, may suggest its role in predicting the biologic behavior of this tumor.
癌症干细胞（CSC）是在许多癌症中负责肿瘤起始、进展和治疗抗性的细胞群体。在本研究中，我们旨在调查干细胞标志物巢蛋白在鳞状细胞癌（SCC）和基底细胞癌（BCC）中的表达模式及临床意义。对样本（23例BCC和22例SCC）进行免疫组织化学检查，以检测巢蛋白的表达及其与相应临床和病理参数的相关性。巢蛋白在23例BCC中的4例（17.4%）中表达，在22例SCC中的10例（45.5%）中表达。两种肿瘤之间的巢蛋白表达具有统计学意义（P = .042）。虽然发现肿瘤分级与巢蛋白表达之间存在直接关系，但结果无统计学意义（P = .495）。本研究结果表明，BCC和SCC可能具有一些共同的细胞起源，但生物学行为不同。巢蛋白表达与SCC分级的关系虽然无统计学意义，但可能提示其在预测该肿瘤生物学行为中的作用。
