胸腺环境对T细胞发育及耐受性的影响。

The effect of thymus environment on T cell development and tolerance.

作者信息

Marrack P, Lo D, Brinster R, Palmiter R, Burkly L, Flavell R H, Kappler J

机构信息

Howard Hughes Medical Institute, National Jewish Center, Department of Medicine, Denver, Colorado.

出版信息

Cell. 1988 May 20;53(4):627-34. doi: 10.1016/0092-8674(88)90578-8.

DOI:10.1016/0092-8674(88)90578-8

PMID:3259471

Abstract

During development in the thymus, T cells are deleted if their receptors are able to recognize self major histocompatibility complex (MHC) proteins. We show that such clonal deletion can occur because of interaction between receptors on T cells and MHC expressed on bone marrow-derived cells. In addition, development in the thymus picks out T cells to mature if their receptors will be restricted for antigen recognition in association with self MHC alleles expressed on thymus epithelial cells. This process is usually thought to involve positive selection of T cells bearing receptors with high and low affinity for MHC on thymus epithelium, and subsequent deletion of high affinity cells by interaction with bone marrow-derived cells. Our data do not fit such a model, but rather suggest that MHC molecules on thymus epithelium and bone marrow-derived cells may not be seen identically by T cell receptors.

摘要

在胸腺发育过程中，如果T细胞的受体能够识别自身主要组织相容性复合体（MHC）蛋白，这些T细胞就会被清除。我们发现，这种克隆清除可能是由于T细胞上的受体与骨髓来源细胞上表达的MHC之间的相互作用所致。此外，如果T细胞的受体与胸腺上皮细胞上表达的自身MHC等位基因结合时能够被限制用于抗原识别，胸腺中的发育会挑选出T细胞使其成熟。通常认为这个过程涉及对胸腺上皮上MHC具有高亲和力和低亲和力受体的T细胞的阳性选择，以及随后通过与骨髓来源细胞相互作用清除高亲和力细胞。我们的数据并不符合这样的模型，而是表明胸腺上皮细胞和骨髓来源细胞上的MHC分子可能不会被T细胞受体同等看待。