Zhang F M, Liu Y F
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University; Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing, Jiangsu 210011, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Jul 10;23(Z1):45-47. doi: 10.3760/cma.j.cn.441530-20200507-00259.
Washed microbiota transplantation (WMT) is a new concept and technique of fecal microbiota transplantation. The delivery routes of WMT include oral capsule, nasogastric tube, nasojejunal tube, gastroscopy, colonic transendoscopic enteral tubing, and anal enema. The research results among different indications or different designs based on the same indication are quite different, partially because of the influence of WMT delivery route. In the process of clinical research design and clinical practice, there are four aspects that affect the decision-making of WMT delivery route: safety, efficacy, cost-effectiveness, and patients' willingness. This article focuses on how to integrate the four aspects mentioned above in the decision-making process of choosing proper delivery of WMT for the final goal of mutual satisfaction between doctors and patients.
经清洗的微生物群移植(WMT)是粪便微生物群移植的一个新概念和技术。WMT的给药途径包括口服胶囊、鼻胃管、鼻空肠管、胃镜、经结肠内镜肠内插管和肛门灌肠。基于相同适应症的不同适应症或不同设计的研究结果差异很大,部分原因是WMT给药途径的影响。在临床研究设计和临床实践过程中,有四个方面会影响WMT给药途径的决策:安全性、有效性、成本效益和患者意愿。本文重点关注如何在选择合适的WMT给药方式的决策过程中整合上述四个方面,以实现医患双方相互满意的最终目标。