Ahmadi-Badejani R, Mosharaf-Dehkordi M, Ahmadikia H
Department of Mechanical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
Comput Methods Biomech Biomed Engin. 2020 Oct;23(13):987-1004. doi: 10.1080/10255842.2020.1782389. Epub 2020 Jun 27.
An image-based numerical algorithm is presented for simulating blood flow through the liver tissue. First, a geometric model is constructed by applying image processing techniques on a real microscopic image of a liver tissue. Then, incompressible blood flow through liver lobules is simulated. Effects of tissue heterogeneity and deformity, presence/absence of the second central vein in a particular lobule, and apparent sinusoids density in the liver cross section on the blood flow are investigated. Numerical results indicate that the existence of thick low permeability vascular septum, high permeability sinusoids, and lobule tissue heterogeneity can considerably affect interlobular and intralobular blood flow.
提出了一种基于图像的数值算法，用于模拟血液在肝组织中的流动。首先，通过对肝脏组织的真实微观图像应用图像处理技术构建几何模型。然后，模拟通过肝小叶的不可压缩血流。研究了组织异质性和变形、特定小叶中第二中央静脉的有无以及肝脏横截面中表观血窦密度对血流的影响。数值结果表明，厚的低渗透性血管间隔、高渗透性血窦的存在以及小叶组织异质性会显著影响小叶间和小叶内的血流。
