Shany S, Chaimovitz C, Yagev R, Bercovich M, Lowenthal M N
Department of Clinical Biochemistry, Soroka Medical Center, Beer Sheva, Israel.
Isr J Med Sci. 1988 Mar;24(3):160-3.
The purpose of the present work was to study the effect of vitamin D and its metabolites in correcting hypovitaminosis D in the elderly. Thirty elderly people (mean age 78.4 years) participated in this study. They all had low serum levels of 25-hydroxyvitamin D (25-OH-D), of 24,25-dihydroxyvitamin D [24,25(OH)2D] and of 1,25-dihydroxyvitamin D [1,25(OH)2D]. These low levels did not increase in nine subjects after oral administration of vitamin D2 (3,000 IU/day for 12 weeks). However, administration of 1 alpha-hydroxyvitamin D3 (1 alpha-OH-D3) to 12 other subjects (0.5 micrograms/day for 8 weeks) led to a significant increase in the serum levels of 1,25(OH)2D. The other vitamin D metabolite levels remained unchanged. A significant increase in the levels of all three main vitamin D metabolites was obtained following administration of 25-hydroxyvitamin D3 (25-OH-D3) to a third group of nine subjects (25 micrograms/day for 1 week). These results suggest that vitamin D nutrition in elderly people insufficently exposed to the sun could be maintained by regular administration of 25-OH-D, whereas the administration of native vitamin D (ergocalciferol) in the doses used was inadequate for vitamin D nutrition.
本研究的目的是探讨维生素D及其代谢产物对纠正老年人维生素D缺乏症的作用。30名老年人（平均年龄78.4岁）参与了本研究。他们的血清25-羟基维生素D（25-OH-D）、24,25-二羟基维生素D[24,25(OH)2D]和1,25-二羟基维生素D[1,25(OH)2D]水平均较低。9名受试者口服维生素D2（3000 IU/天，共12周）后，这些低水平并未升高。然而，另外12名受试者服用1α-羟基维生素D3（1α-OH-D3，0.5微克/天，共8周）后，血清1,25(OH)2D水平显著升高。其他维生素D代谢产物水平保持不变。第三组9名受试者服用25-羟基维生素D3（25-OH-D3，25微克/天，共1周）后，所有三种主要维生素D代谢产物的水平均显著升高。这些结果表明，对于日照不足的老年人，定期服用25-OH-D可维持其维生素D营养状况，而所用剂量的天然维生素D（麦角钙化醇）不足以满足维生素D营养需求。
