Ju Mengxi, Li Xinwei, Li Zhangyong
Biomedical Engineering Research Center, The Chongqing University of Posts and Telecommunications, Chongqing 400065, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Jun 25;37(3):519-526. doi: 10.7507/1001-5515.201909040.
The number of white blood cells in the leucorrhea microscopic image can indicate the severity of vaginal inflammation. At present, the detection of white blood cells in leucorrhea mainly relies on manual microscopy by medical experts, which is time-consuming, expensive and error-prone. In recent years, some studies have proposed to implement intelligent detection of leucorrhea white blood cells based on deep learning technology. However, such methods usually require manual labeling of a large number of samples as training sets, and the labeling cost is high. Therefore, this study proposes the use of deep active learning algorithms to achieve intelligent detection of white blood cells in leucorrhea microscopic images. In the active learning framework, a small number of labeled samples were firstly used as the basic training set, and a faster region convolutional neural network (Faster R-CNN) training detection model was performed. Then the most valuable samples were automatically selected for manual annotation, and the training set and the corresponding detection model were iteratively updated, which made the performance of the model continue to increase. The experimental results show that the deep active learning technology can obtain higher detection accuracy under less manual labeling samples, and the average precision of white blood cell detection could reach 90.6%, which meets the requirements of clinical routine examination.
白带显微图像中的白细胞数量可表明阴道炎症的严重程度。目前,白带中白细胞的检测主要依靠医学专家进行人工显微镜检查,这既耗时、成本高又容易出错。近年来,一些研究提出基于深度学习技术实现白带白细胞的智能检测。然而,此类方法通常需要人工标注大量样本作为训练集,标注成本很高。因此,本研究提出使用深度主动学习算法来实现白带显微图像中白细胞的智能检测。在主动学习框架中,首先使用少量标注样本作为基础训练集,进行更快区域卷积神经网络(Faster R-CNN)训练检测模型。然后自动选择最有价值的样本进行人工标注,并对训练集和相应的检测模型进行迭代更新,使得模型性能不断提高。实验结果表明,深度主动学习技术在较少人工标注样本的情况下能够获得较高的检测精度,白细胞检测的平均精度可达90.6%,满足临床常规检查的要求。