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本文引用的文献

1
Automatic identification of fungi in microscopic leucorrhea images.显微镜下白带图像中真菌的自动识别。
J Opt Soc Am A Opt Image Sci Vis. 2017 Sep 1;34(9):1484-1489. doi: 10.1364/JOSAA.34.001484.
2
Collaborative Active Visual Recognition from Crowds: A Distributed Ensemble Approach.协同式众包主动视觉识别:一种分布式集成方法。
IEEE Trans Pattern Anal Mach Intell. 2018 Mar;40(3):582-594. doi: 10.1109/TPAMI.2017.2682082. Epub 2017 Mar 15.
3
Efficient leukocyte segmentation and recognition in peripheral blood image.外周血图像中高效的白细胞分割与识别
Technol Health Care. 2016 May 18;24(3):335-47. doi: 10.3233/THC-161133.
4
Segmentation of white blood cells and comparison of cell morphology by linear and naïve Bayes classifiers.白细胞的分割以及通过线性和朴素贝叶斯分类器对细胞形态的比较。
Biomed Eng Online. 2015 Jun 30;14:63. doi: 10.1186/s12938-015-0037-1.
5
Leucocyte classification for leukaemia detection using image processing techniques.利用图像处理技术进行白血病检测的白细胞分类
Artif Intell Med. 2014 Nov;62(3):179-91. doi: 10.1016/j.artmed.2014.09.002. Epub 2014 Sep 16.
6
Leukorrhea and bacterial vaginosis as in-office predictors of cervical infection in high-risk women.白带和细菌性阴道病作为高危女性宫颈感染的门诊预测指标。
Obstet Gynecol. 2002 Oct;100(4):808-12. doi: 10.1016/s0029-7844(02)02147-6.

基于深度主动学习的微观白带图像中白细胞检测

[Detection of white blood cells in microscopic leucorrhea images based on deep active learning].

作者信息

Ju Mengxi, Li Xinwei, Li Zhangyong

机构信息

Biomedical Engineering Research Center, The Chongqing University of Posts and Telecommunications, Chongqing 400065, P.R.China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Jun 25;37(3):519-526. doi: 10.7507/1001-5515.201909040.

DOI:10.7507/1001-5515.201909040
PMID:32597095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10319563/
Abstract

The number of white blood cells in the leucorrhea microscopic image can indicate the severity of vaginal inflammation. At present, the detection of white blood cells in leucorrhea mainly relies on manual microscopy by medical experts, which is time-consuming, expensive and error-prone. In recent years, some studies have proposed to implement intelligent detection of leucorrhea white blood cells based on deep learning technology. However, such methods usually require manual labeling of a large number of samples as training sets, and the labeling cost is high. Therefore, this study proposes the use of deep active learning algorithms to achieve intelligent detection of white blood cells in leucorrhea microscopic images. In the active learning framework, a small number of labeled samples were firstly used as the basic training set, and a faster region convolutional neural network (Faster R-CNN) training detection model was performed. Then the most valuable samples were automatically selected for manual annotation, and the training set and the corresponding detection model were iteratively updated, which made the performance of the model continue to increase. The experimental results show that the deep active learning technology can obtain higher detection accuracy under less manual labeling samples, and the average precision of white blood cell detection could reach 90.6%, which meets the requirements of clinical routine examination.

摘要

白带显微图像中的白细胞数量可表明阴道炎症的严重程度。目前,白带中白细胞的检测主要依靠医学专家进行人工显微镜检查,这既耗时、成本高又容易出错。近年来,一些研究提出基于深度学习技术实现白带白细胞的智能检测。然而,此类方法通常需要人工标注大量样本作为训练集,标注成本很高。因此,本研究提出使用深度主动学习算法来实现白带显微图像中白细胞的智能检测。在主动学习框架中,首先使用少量标注样本作为基础训练集,进行更快区域卷积神经网络(Faster R-CNN)训练检测模型。然后自动选择最有价值的样本进行人工标注,并对训练集和相应的检测模型进行迭代更新,使得模型性能不断提高。实验结果表明,深度主动学习技术在较少人工标注样本的情况下能够获得较高的检测精度,白细胞检测的平均精度可达90.6%,满足临床常规检查的要求。