Department of Obstetrics and Gynecology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Resident of Anaesthesiology, Mazandaran University of Medical Science, Sari, Iran.
Endocr Regul. 2020 Apr 1;54(2):119-125. doi: 10.2478/enr-2020-0014.
Pregnancy can cause diabetic conditions and gestational diabetes is the most common metabolic disorder of the era. Scientific evidence suggests that obesity increases the incidence and severity of gestational diabetes. Adipokines are proteins secreted from adipose tissue in response to extracellular stimuli and altered metabolism. These hormones are involved in regulating the energy balance, lipid metabolism, and insulin sensitivity. One of the types of adipokines is called adiponectin, which has anti-diabetic, anti-inflammatory, and anti-atherogenic effects. Accordingly, this study is aimed to investigate the correlation between the serum adiponectin level with the gestational diabetes and the postpartum metabolic syndrome.
This case-control study was carried out on 37 pregnant women (in Sari, Iran) with gestational diabetes and 37 non-diabetic pregnant women who were matched regarding age and body mass index (BMI). Serum adiponectin and glucose levels were measured. Finally, six weeks after termination of pregnancy, women in both groups were evaluated for metabolic syndrome. All statistical analyses of this study were performed using IBM SPSS software version 21 and, in all cases, the two-way p value less than 0.05 was considered statistically significant.
The mean age of pregnant women was 28.46±4.11 years in the non-diabetic group and 30.03±4.71 in the diabetic group. There was no statistically significant difference found between the mean age (p=0.123) and BMI (p=0.727) in two groups. Serum adiponectin levels in the diabetic group (5.51±3.15 µg/ml) were significantly lower than in the non-diabetic group (8.35±4.54 µg/ml) (p=0.003). In the diabetic group, serum adiponectin level did not correlate with the maternal age, maternal BMI, and postpartum metabolic syndrome (p>0.005).
The results of the present study indicate a correlation of low adiponectin concentrations with gestational diabetes, but this association with postpartum metabolic syndrome is uncertain. However, to elucidate the mechanism of adiponectin in predicting gestational diabetes and postpartum metabolic syndrome further studies are required.
妊娠可导致糖尿病，妊娠期糖尿病是当前最常见的代谢紊乱。有科学证据表明，肥胖会增加妊娠期糖尿病的发病率和严重程度。脂肪细胞因子是脂肪组织对细胞外刺激和代谢改变作出反应而分泌的蛋白。这些激素参与调节能量平衡、脂代谢和胰岛素敏感性。脂肪细胞因子的一种类型称为脂联素，具有抗糖尿病、抗炎和抗动脉粥样硬化的作用。因此，本研究旨在探讨血清脂联素水平与妊娠期糖尿病和产后代谢综合征的相关性。
本病例对照研究在伊朗萨里的 37 名患有妊娠期糖尿病的孕妇（病例组）和 37 名年龄和体重指数（BMI）相匹配的非糖尿病孕妇（对照组）中进行。测量血清脂联素和葡萄糖水平。最后，在妊娠终止后 6 周，评估两组妇女的代谢综合征。本研究的所有统计分析均使用 IBM SPSS 软件版本 21 进行，所有情况下，双尾 p 值小于 0.05 被认为具有统计学意义。
非糖尿病组孕妇的平均年龄为 28.46±4.11 岁，糖尿病组为 30.03±4.71 岁。两组的平均年龄（p=0.123）和 BMI（p=0.727）无统计学差异。糖尿病组血清脂联素水平（5.51±3.15 µg/ml）明显低于非糖尿病组（8.35±4.54 µg/ml）（p=0.003）。在糖尿病组，血清脂联素水平与产妇年龄、产妇 BMI 和产后代谢综合征无关（p＞0.005）。
本研究结果表明，低脂联素浓度与妊娠期糖尿病相关，但与产后代谢综合征的相关性尚不确定。然而，要阐明脂联素在预测妊娠期糖尿病和产后代谢综合征中的机制，还需要进一步研究。
